CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity
The regulation of cell growth and division occurs in an accurate sequential manner. It is dictated by the accumulation of cyclins (CCNs) and cyclin-dependent kinases (CDKs) complexes and degradation of CCNs. In human tumors, instead, the cell cycle is deregulated, causing absence of differentiation...
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Online Access: | http://dx.doi.org/10.1155/2014/361020 |
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doaj-cac5aa0312b54fcdb89d141ac87386852020-11-24T23:54:46ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/361020361020CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic PredictivityPatrizia Bonelli0Franca Maria Tuccillo1Antonella Borrelli2Antonietta Schiattarella3Franco Maria Buonaguro4Molecular Biology and Viral Oncology Unit, Department of Research, Istituto Nazionale Tumori-IRCCS Fondazione “G. Pascale”, 80131 Naples, ItalyMolecular Biology and Viral Oncology Unit, Department of Research, Istituto Nazionale Tumori-IRCCS Fondazione “G. Pascale”, 80131 Naples, ItalyMolecular Biology and Viral Oncology Unit, Department of Research, Istituto Nazionale Tumori-IRCCS Fondazione “G. Pascale”, 80131 Naples, ItalyMolecular Biology and Viral Oncology Unit, Department of Research, Istituto Nazionale Tumori-IRCCS Fondazione “G. Pascale”, 80131 Naples, ItalyMolecular Biology and Viral Oncology Unit, Department of Research, Istituto Nazionale Tumori-IRCCS Fondazione “G. Pascale”, 80131 Naples, ItalyThe regulation of cell growth and division occurs in an accurate sequential manner. It is dictated by the accumulation of cyclins (CCNs) and cyclin-dependent kinases (CDKs) complexes and degradation of CCNs. In human tumors, instead, the cell cycle is deregulated, causing absence of differentiation and aberrant cell growth. Oncogenic alterations of CCNs, CDKs, and CDKIs have been reported in more than 90% of human cancers, and the most frequent are those related to the G1 phase. Several molecular mechanisms, including gene overexpression, chromosomal translocations, point mutations, insertions and deletions, missense and frame shift mutation, splicing, or methylation, may be responsible for these alterations. The cell cycle regulators are involved in tumor progression given their association with cancers characterized by higher incidence of relapses and chemotherapy resistance. In the last decade anticancer drug researches focused on new compounds, able to target molecules related to changes in genes associated with tumor status. Recently, the studies have focused on the restoration of cell cycle control modulating molecular targets involved in cancer-cell alterations. This paper aims to correlate alterations of cell cycle regulators with human cancers and therapeutic responsivity.http://dx.doi.org/10.1155/2014/361020 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patrizia Bonelli Franca Maria Tuccillo Antonella Borrelli Antonietta Schiattarella Franco Maria Buonaguro |
spellingShingle |
Patrizia Bonelli Franca Maria Tuccillo Antonella Borrelli Antonietta Schiattarella Franco Maria Buonaguro CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity BioMed Research International |
author_facet |
Patrizia Bonelli Franca Maria Tuccillo Antonella Borrelli Antonietta Schiattarella Franco Maria Buonaguro |
author_sort |
Patrizia Bonelli |
title |
CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity |
title_short |
CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity |
title_full |
CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity |
title_fullStr |
CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity |
title_full_unstemmed |
CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity |
title_sort |
cdk/ccn and cdki alterations for cancer prognosis and therapeutic predictivity |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
The regulation of cell growth and division occurs in an accurate sequential manner. It is dictated by the accumulation of cyclins (CCNs) and cyclin-dependent kinases (CDKs) complexes and degradation of CCNs. In human tumors, instead, the cell cycle is deregulated, causing absence of differentiation and aberrant cell growth. Oncogenic alterations of CCNs, CDKs, and CDKIs have been reported in more than 90% of human cancers, and the most frequent are those related to the G1 phase. Several molecular mechanisms, including gene overexpression, chromosomal translocations, point mutations, insertions and deletions, missense and frame shift mutation, splicing, or methylation, may be responsible for these alterations. The cell cycle regulators are involved in tumor progression given their association with cancers characterized by higher incidence of relapses and chemotherapy resistance. In the last decade anticancer drug researches focused on new compounds, able to target molecules related to changes in genes associated with tumor status. Recently, the studies have focused on the restoration of cell cycle control modulating molecular targets involved in cancer-cell alterations. This paper aims to correlate alterations of cell cycle regulators with human cancers and therapeutic responsivity. |
url |
http://dx.doi.org/10.1155/2014/361020 |
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