The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells
Objective: Curcuminoids (including curcumin) are natural antioxidants demonstrating potent chemopreventive properties against several forms of cancer. This study investigated the antiproliferative and induced apoptotic effects of curcuminoids on three cell lines isolated from human breast adenocarci...
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doaj-cacfc711d8184cd48ecfe41b2e737fda2020-11-24T22:36:28ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592012-09-0151336837410.1016/j.tjog.2012.07.009The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cellsChi-Chang Chang0Chi-Feng Fu1Wei-Te Yang2Tzu-Yu Chen3Yi-Chiang Hsu4Department of Obstetrics and Gynecology, E-Da Hospital, I-Shou University, Kaohsiung, TaiwanDepartment of Obstetrics and Gynecology, E-Da Hospital, I-Shou University, Kaohsiung, TaiwanGraduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Bioscience Technology, College of Health Sciences, Chang Jung Christian University, Tainan, TaiwanInnovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, Tainan, TaiwanObjective: Curcuminoids (including curcumin) are natural antioxidants demonstrating potent chemopreventive properties against several forms of cancer. This study investigated the antiproliferative and induced apoptotic effects of curcuminoids on three cell lines isolated from human breast adenocarcinoma and ductal carcinoma (MDA-MB-231, MDA-MB-435S, and MCF-7). Materials and Methods: This study developed a highly sensitive, reproducible assay method using high-pressure liquid chromatography to quantify the cellular uptake of curcuminoids by breast cancer cells and quantitate its effect on inhibition of proliferation and activation of apoptosis in breast cancer cells. Results: Results indicate that curcuminoids inhibited cell proliferation and activation of apoptosis in the cell lines in this study. Both effects were observed to increase in proportion to the cellular uptake of curcuminoids; cellular uptake increased following an increase in the dosage of curcuminoids. Conclusion: The inhibition of proliferation and increased apoptosis of breast cancer cells appears to be associated with the uptake of curcuminoids by cancer cells.http://www.sciencedirect.com/science/article/pii/S1028455912001234apoptosisbreast cancercellular uptakecurcuminoids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chi-Chang Chang Chi-Feng Fu Wei-Te Yang Tzu-Yu Chen Yi-Chiang Hsu |
spellingShingle |
Chi-Chang Chang Chi-Feng Fu Wei-Te Yang Tzu-Yu Chen Yi-Chiang Hsu The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells Taiwanese Journal of Obstetrics & Gynecology apoptosis breast cancer cellular uptake curcuminoids |
author_facet |
Chi-Chang Chang Chi-Feng Fu Wei-Te Yang Tzu-Yu Chen Yi-Chiang Hsu |
author_sort |
Chi-Chang Chang |
title |
The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells |
title_short |
The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells |
title_full |
The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells |
title_fullStr |
The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells |
title_full_unstemmed |
The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells |
title_sort |
cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells |
publisher |
Elsevier |
series |
Taiwanese Journal of Obstetrics & Gynecology |
issn |
1028-4559 |
publishDate |
2012-09-01 |
description |
Objective: Curcuminoids (including curcumin) are natural antioxidants demonstrating potent chemopreventive properties against several forms of cancer. This study investigated the antiproliferative and induced apoptotic effects of curcuminoids on three cell lines isolated from human breast adenocarcinoma and ductal carcinoma (MDA-MB-231, MDA-MB-435S, and MCF-7).
Materials and Methods: This study developed a highly sensitive, reproducible assay method using high-pressure liquid chromatography to quantify the cellular uptake of curcuminoids by breast cancer cells and quantitate its effect on inhibition of proliferation and activation of apoptosis in breast cancer cells.
Results: Results indicate that curcuminoids inhibited cell proliferation and activation of apoptosis in the cell lines in this study. Both effects were observed to increase in proportion to the cellular uptake of curcuminoids; cellular uptake increased following an increase in the dosage of curcuminoids.
Conclusion: The inhibition of proliferation and increased apoptosis of breast cancer cells appears to be associated with the uptake of curcuminoids by cancer cells. |
topic |
apoptosis breast cancer cellular uptake curcuminoids |
url |
http://www.sciencedirect.com/science/article/pii/S1028455912001234 |
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