Assessment of inflammatory mediator, intestinal flora and Fas/FasL expression in patients with acute pancreatitis after lactulose combined with somatostatin therapy

• Main Authors: Bing-Li Zheng, Jie Peng, Aihemaiti•baikere
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-11-01
• Series: Journal of Hainan Medical University
• Subjects: Acute pancreatitis; Lactulose; Inflammatory mediator; Intestinal flora disturbance
• Online Access: http://www.hnykdxxb.com/PDF/201622/24.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of lactulose combined with somatostatin therapy on inflammatory mediator, intestinal flora and Fas/FasL expression in patients with acute pancreatitis. Methods: A total of 56 patients with acute pancreatitis treated in our hospital between May 2013 and October 2015 were randomly divided into group A and group B, group A received lactulose, somatostatin combined with conventional therapy and group B received somatostatin combined with conventional therapy. Three days after treatment, the levels of inflammatory mediators, sFas and sFasL in serum, the expression of Fas and FasL in peripheral blood as well as the copy number of intestinal flora in feces tissue were determined. Results: Three days after treatment, IL-1β, IL-6, IL-8, IL-10, IL-18, sFas and sFasL content in serum of group A were significantly lower than those of group B, Fas and FasL mRNA content and protein content in peripheral blood were significantly lower than those of group B, lactobacillus, bifidobacterium and bacteroides content in feces tissue were significantly higher than those of group B, and Escherichia coli, enterococcus and proteus content in feces tissue were significantly lower than those of group B. Conclusions: Lactulose combined with somatostatin treatment of acute pancreatitis can improve the intestinal mucosal barrier function, correct intestinal flora disturbance, relieve inflammation and inhibit the immunosuppression mediated by Fas/FasL.