DNA methylation perturbations in genes involved in polyunsaturated fatty acid biosynthesis associated with depression and suicide risk

DNA methylation perturbations in genes involved in polyunsaturated fatty acid biosynthesis associated with depression and suicide risk

Polyunsaturated fatty acid (PUFA) status has been associated with neuropsychiatric disorders, including depression and risk of suicide. Long-chain PUFAs (LC-PUFAs) are obtained in the diet or produced by sequential desaturation and elongation of shorter-chain precursor fatty acids linoleic acid (LA,...

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Bibliographic Details
Main Authors: Fatemeh eHaghighi, Hanga eGalfalvy, Sean eChen, Yung-Yu eHuang, Thomas B. Cooper, Ainsley K. Burke, Maria A Oquendo, J. John eMann, M. Elizabeth eSublette
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Neurology
Subjects:
DNA Methylation
Fatty Acids, Omega-3
epigenetics
polyunsaturated fatty acids
Major Depressive Disorder
omega-6 fatty acids
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00092/full

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http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00092/full

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