Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin

Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin

Objective: The mechanisms that lead to endothelial cell (EC) injury and propagate the vasculopathy in Systemic Sclerosis (SSc) are not well understood. Using single cell RNA sequencing (scRNA-seq), our goal was to identify EC markers and signature pathways associated with vascular injury in SSc skin...

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Bibliographic Details
Main Authors: Sokratis A. Apostolidis, Giuseppina Stifano, Tracy Tabib, Lisa M. Rice, Christina M. Morse, Bashar Kahaleh, Robert Lafyatis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
ScRNA-seq
HSPG2
APLNR
systemic sclerosis
endothelial dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02191/full

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