Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases
ABSTRACT Tubulointerstitial nephritis and uveitis syndrome is a rare and probably underdiagnosed condition. Renal and ocular manifestations may not occur simultaneously, making the diagnosis more difficult. Nephritis may be asymptomatic; therefore, renal function evaluation is essential for diagnosi...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Nefrologia
2018-06-01
|
Series: | Brazilian Journal of Nephrology |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018005016101&lng=en&tlng=en |
id |
doaj-caeae487169347e2b26738e9bcd41306 |
---|---|
record_format |
Article |
spelling |
doaj-caeae487169347e2b26738e9bcd413062020-11-24T21:27:50ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392018-06-01010.1590/2175-8239-jbn-2018-0015S0101-28002018005016101Tubulointerstitial nephritis and uveitis syndrome in children: report of three casesCátia PereiraJoana GilInês LealPatrícia Costa-ReisJosé Eduardo Esteves Da SilvaRosário StoneABSTRACT Tubulointerstitial nephritis and uveitis syndrome is a rare and probably underdiagnosed condition. Renal and ocular manifestations may not occur simultaneously, making the diagnosis more difficult. Nephritis may be asymptomatic; therefore, renal function evaluation is essential for diagnosis. Urinary β2-microglobulin levels may be particularly useful. Uveitis, mostly anterior, nongranulomatous and bilateral, occurs usually after the onset of nephritis. Treatment includes corticosteroids and, eventually, other immunosuppressant agents. Renal disease is usually benign and resolves spontaneously or after treatment with systemic corticosteroids. Uveitis, however, may be chronic or recurrent. The authors described the cases of three pediatric patients diagnosed with tubulointerstitial nephritis and uveitis syndrome. The goal of this paper was to warn the medical community over the need to screen patients with uveitis for renal disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018005016101&lng=en&tlng=enbeta 2-MicroglobulinNephritis, InterstitialUveitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cátia Pereira Joana Gil Inês Leal Patrícia Costa-Reis José Eduardo Esteves Da Silva Rosário Stone |
spellingShingle |
Cátia Pereira Joana Gil Inês Leal Patrícia Costa-Reis José Eduardo Esteves Da Silva Rosário Stone Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases Brazilian Journal of Nephrology beta 2-Microglobulin Nephritis, Interstitial Uveitis |
author_facet |
Cátia Pereira Joana Gil Inês Leal Patrícia Costa-Reis José Eduardo Esteves Da Silva Rosário Stone |
author_sort |
Cátia Pereira |
title |
Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases |
title_short |
Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases |
title_full |
Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases |
title_fullStr |
Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases |
title_full_unstemmed |
Tubulointerstitial nephritis and uveitis syndrome in children: report of three cases |
title_sort |
tubulointerstitial nephritis and uveitis syndrome in children: report of three cases |
publisher |
Sociedade Brasileira de Nefrologia |
series |
Brazilian Journal of Nephrology |
issn |
2175-8239 |
publishDate |
2018-06-01 |
description |
ABSTRACT Tubulointerstitial nephritis and uveitis syndrome is a rare and probably underdiagnosed condition. Renal and ocular manifestations may not occur simultaneously, making the diagnosis more difficult. Nephritis may be asymptomatic; therefore, renal function evaluation is essential for diagnosis. Urinary β2-microglobulin levels may be particularly useful. Uveitis, mostly anterior, nongranulomatous and bilateral, occurs usually after the onset of nephritis. Treatment includes corticosteroids and, eventually, other immunosuppressant agents. Renal disease is usually benign and resolves spontaneously or after treatment with systemic corticosteroids. Uveitis, however, may be chronic or recurrent. The authors described the cases of three pediatric patients diagnosed with tubulointerstitial nephritis and uveitis syndrome. The goal of this paper was to warn the medical community over the need to screen patients with uveitis for renal disease. |
topic |
beta 2-Microglobulin Nephritis, Interstitial Uveitis |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018005016101&lng=en&tlng=en |
work_keys_str_mv |
AT catiapereira tubulointerstitialnephritisanduveitissyndromeinchildrenreportofthreecases AT joanagil tubulointerstitialnephritisanduveitissyndromeinchildrenreportofthreecases AT inesleal tubulointerstitialnephritisanduveitissyndromeinchildrenreportofthreecases AT patriciacostareis tubulointerstitialnephritisanduveitissyndromeinchildrenreportofthreecases AT joseeduardoestevesdasilva tubulointerstitialnephritisanduveitissyndromeinchildrenreportofthreecases AT rosariostone tubulointerstitialnephritisanduveitissyndromeinchildrenreportofthreecases |
_version_ |
1725973120053936128 |