Cytotoxicity of Two Species of Glaucium from Iran
Background: Numerous molecules in Papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. Objective: Numerous molecules in this family display interesting cytotoxic activities against...
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Institue of Medicinal Plants, ACECR
2013-02-01
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doaj-caedee4595fd470790014f34277d00ab2021-09-19T04:25:28ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582013-02-0112458592Cytotoxicity of Two Species of Glaucium from IranF Hadjiakhoondi0SN Ostad1M Khanavi2A Hadjiakhoondi3B Farahanikia4A Salarytabar5 Department of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences Department of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences Department of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences Department of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences Department of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences Background: Numerous molecules in Papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. Objective: Numerous molecules in this family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. In this study we evaluated the cytotoxic effects of total and alkaloid extracts of Glaucium flavum Crantz and Glaucium grandiflurom Boiss. & Huet, the two species of this genus, on cell proliferation of HT-29, Caco-2, T47D, and NIH/3T3 cell lines by MTT method and their IC50s were determined. Methods: The aerial parts of G. grandiflurom and G. flavum were collected from Jajrud in Tehran Province in June 2011. The effect of total extract and alkaloid extract of them on HT-29, Ta7D, NIH/3T3 and Caco-2 cells was determined by MTT assay. Results: Alkaloid extracts showed a moderate cytotoxic effect on the cell lines. IC50 values confirmed that the growth and proliferation of NIH/3T3 cells were less affected in comparison to other cell lines. Conclusion: The effects of alkaloid extracts of both plants on human colon adenocarcinoma cell lines (HT-29, Caco-2), showed that these extracts contain certain compounds that can inhibit the proliferation of colon cancerous cells.http://jmp.ir/article-1-112-en.htmlcytotoxicityglaucium flavumglaucium grandiflurommtt |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
F Hadjiakhoondi SN Ostad M Khanavi A Hadjiakhoondi B Farahanikia A Salarytabar |
spellingShingle |
F Hadjiakhoondi SN Ostad M Khanavi A Hadjiakhoondi B Farahanikia A Salarytabar Cytotoxicity of Two Species of Glaucium from Iran Journal of Medicinal Plants cytotoxicity glaucium flavum glaucium grandiflurom mtt |
author_facet |
F Hadjiakhoondi SN Ostad M Khanavi A Hadjiakhoondi B Farahanikia A Salarytabar |
author_sort |
F Hadjiakhoondi |
title |
Cytotoxicity of Two Species of Glaucium from Iran |
title_short |
Cytotoxicity of Two Species of Glaucium from Iran |
title_full |
Cytotoxicity of Two Species of Glaucium from Iran |
title_fullStr |
Cytotoxicity of Two Species of Glaucium from Iran |
title_full_unstemmed |
Cytotoxicity of Two Species of Glaucium from Iran |
title_sort |
cytotoxicity of two species of glaucium from iran |
publisher |
Institue of Medicinal Plants, ACECR |
series |
Journal of Medicinal Plants |
issn |
2717-204X 2717-2058 |
publishDate |
2013-02-01 |
description |
Background: Numerous molecules in Papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. Objective: Numerous molecules in this family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. In this study we evaluated the cytotoxic effects of total and alkaloid extracts of Glaucium flavum Crantz and Glaucium grandiflurom Boiss. & Huet, the two species of this genus, on cell proliferation of HT-29, Caco-2, T47D, and NIH/3T3 cell lines by MTT method and their IC50s were determined. Methods: The aerial parts of G. grandiflurom and G. flavum were collected from Jajrud in Tehran Province in June 2011. The effect of total extract and alkaloid extract of them on HT-29, Ta7D, NIH/3T3 and Caco-2 cells was determined by MTT assay. Results: Alkaloid extracts showed a moderate cytotoxic effect on the cell lines. IC50 values confirmed that the growth and proliferation of NIH/3T3 cells were less affected in comparison to other cell lines. Conclusion: The effects of alkaloid extracts of both plants on human colon adenocarcinoma cell lines (HT-29, Caco-2), showed that these extracts contain certain compounds that can inhibit the proliferation of colon cancerous cells. |
topic |
cytotoxicity glaucium flavum glaucium grandiflurom mtt |
url |
http://jmp.ir/article-1-112-en.html |
work_keys_str_mv |
AT fhadjiakhoondi cytotoxicityoftwospeciesofglauciumfromiran AT snostad cytotoxicityoftwospeciesofglauciumfromiran AT mkhanavi cytotoxicityoftwospeciesofglauciumfromiran AT ahadjiakhoondi cytotoxicityoftwospeciesofglauciumfromiran AT bfarahanikia cytotoxicityoftwospeciesofglauciumfromiran AT asalarytabar cytotoxicityoftwospeciesofglauciumfromiran |
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1717376679728381952 |