Abnormal Mitochondrial cAMP/PKA Signaling Is Involved in Sepsis-Induced Mitochondrial and Myocardial Dysfunction

Abnormal Mitochondrial cAMP/PKA Signaling Is Involved in Sepsis-Induced Mitochondrial and Myocardial Dysfunction

Adrenergic receptors couple to Gs-proteins leading to transmembrane adenylyl cyclase activation and cytosolic cyclic adenosine monophosphate (cAMP) production. Cyclic AMP is also produced in the mitochondrial matrix, where it regulates respiration through protein kinase A (PKA)-dependent phosphoryla...

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Bibliographic Details
Main Authors: Remi Neviere, Florian Delguste, Arthur Durand, Jocelyn Inamo, Eric Boulanger, Sebastien Preau
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria respiration
cyclic adenosine monophosphate (cAMP)
protein kinase A
soluble adenylyl cyclase
phosphodiesterase
isolated heart
sepsis
Online Access:http://www.mdpi.com/1422-0067/17/12/2075

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