Predicting process design spaces for spray drying amorphous solid dispersions

Predicting process design spaces for spray drying amorphous solid dispersions

Amorphous solid dispersions (ASDs) are commonly manufactured using spray-drying processes. The product quality can be decisively influenced by the choice of process parameters. Following the quality-by-design approach, the identification of the spray-drying process design space is thus an integral t...

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Bibliographic Details
Main Authors: Stefanie Dohrn, Pranay Rawal, Christian Luebbert, Kristin Lehmkemper, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Amorphous solid dispersion
Residual solvent
Spray drying
Solvent selection
PC-SAFT
Process design space
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156721000013

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http://www.sciencedirect.com/science/article/pii/S2590156721000013

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