Novel Nondietary Therapies for Celiac DiseaseSummary
Celiac Disease (CeD) is defined as a chronic small intestinal immune-mediated enteropathy that is precipitated by exposure to dietary gluten in genetically predisposed individuals. CeD is one of the most common autoimmune disorders affecting around 1% of the population worldwide. Currently, the only...
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doaj-caf97d53661845168e39a5d1f0a0f69a2020-11-25T00:57:28ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2019-01-0183335345Novel Nondietary Therapies for Celiac DiseaseSummaryEaman Alhassan0Abhijeet Yadav1Ciaran P. Kelly2Rupa Mukherjee3Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MassachusettsDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MassachusettsDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MassachusettsCorrespondence Address correspondence to: Rupa Mukherjee, MD, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215. fax: (617) 667-5826.; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MassachusettsCeliac Disease (CeD) is defined as a chronic small intestinal immune-mediated enteropathy that is precipitated by exposure to dietary gluten in genetically predisposed individuals. CeD is one of the most common autoimmune disorders affecting around 1% of the population worldwide. Currently, the only acceptable treatment for CeD is strict, lifelong adherence to a gluten-free diet (GFD) which can often present a challenging task. A GFD alone is not sufficient to control symptoms and prevent mucosal damage that can result from unintentional gluten exposure. Moreover, long-term complications can occur in many patients. Consequently, there is an unmet need for non-dietary therapies for the management of CeD. Such therapies could serve as an adjunct to the GFD but eventually may replace it. This review will focus on and discuss non-dietary therapies currently in clinical development for the management of CeD. Methodology: We searched clinicaltrials.gov and PubMed to extract articles about celiac disease. We used keywords including, but not limited to, “celiac disease,” “non-dietary,” “therapeutics,” “pathophysiology,” “Endopeptidases,” “tight junction modulators,” “vaccine,” and “Nexvax2”. We focused mainly on articles that conducted pathophysiologic and therapeutic research in human trials. Keywords: Celiac Disease, Drug Therapy, Latiglutenase, Larazotide Acetate, Nexvax2, Necator americanushttp://www.sciencedirect.com/science/article/pii/S2352345X19300657 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eaman Alhassan Abhijeet Yadav Ciaran P. Kelly Rupa Mukherjee |
spellingShingle |
Eaman Alhassan Abhijeet Yadav Ciaran P. Kelly Rupa Mukherjee Novel Nondietary Therapies for Celiac DiseaseSummary Cellular and Molecular Gastroenterology and Hepatology |
author_facet |
Eaman Alhassan Abhijeet Yadav Ciaran P. Kelly Rupa Mukherjee |
author_sort |
Eaman Alhassan |
title |
Novel Nondietary Therapies for Celiac DiseaseSummary |
title_short |
Novel Nondietary Therapies for Celiac DiseaseSummary |
title_full |
Novel Nondietary Therapies for Celiac DiseaseSummary |
title_fullStr |
Novel Nondietary Therapies for Celiac DiseaseSummary |
title_full_unstemmed |
Novel Nondietary Therapies for Celiac DiseaseSummary |
title_sort |
novel nondietary therapies for celiac diseasesummary |
publisher |
Elsevier |
series |
Cellular and Molecular Gastroenterology and Hepatology |
issn |
2352-345X |
publishDate |
2019-01-01 |
description |
Celiac Disease (CeD) is defined as a chronic small intestinal immune-mediated enteropathy that is precipitated by exposure to dietary gluten in genetically predisposed individuals. CeD is one of the most common autoimmune disorders affecting around 1% of the population worldwide. Currently, the only acceptable treatment for CeD is strict, lifelong adherence to a gluten-free diet (GFD) which can often present a challenging task. A GFD alone is not sufficient to control symptoms and prevent mucosal damage that can result from unintentional gluten exposure. Moreover, long-term complications can occur in many patients. Consequently, there is an unmet need for non-dietary therapies for the management of CeD. Such therapies could serve as an adjunct to the GFD but eventually may replace it. This review will focus on and discuss non-dietary therapies currently in clinical development for the management of CeD. Methodology: We searched clinicaltrials.gov and PubMed to extract articles about celiac disease. We used keywords including, but not limited to, “celiac disease,” “non-dietary,” “therapeutics,” “pathophysiology,” “Endopeptidases,” “tight junction modulators,” “vaccine,” and “Nexvax2”. We focused mainly on articles that conducted pathophysiologic and therapeutic research in human trials. Keywords: Celiac Disease, Drug Therapy, Latiglutenase, Larazotide Acetate, Nexvax2, Necator americanus |
url |
http://www.sciencedirect.com/science/article/pii/S2352345X19300657 |
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