Elimination of SOX2/OCT4-Associated Prostate Cancer Stem Cells Blocks Tumor Development and Enhances Therapeutic Response

Elimination of SOX2/OCT4-Associated Prostate Cancer Stem Cells Blocks Tumor Development and Enhances Therapeutic Response

SOX2 and OCT4 are key regulators of embryonic stem cell pluripotency. They are overexpressed in prostate cancers and have been associated with cancer stem cell (CSC) properties. However, reliable tools for detecting and targeting SOX2/OCT4-overexpressing cells are lacking, limiting our understanding...

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Bibliographic Details
Main Authors: Prasanna Kumar Vaddi, Mark A. Stamnes, Huojun Cao, Songhai Chen
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
cancer stem cells
SORE6 reporter
SOX2
OCT4
prostate cancer
suicide gene
Online Access:https://www.mdpi.com/2072-6694/11/9/1331

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