Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can be neuroprotective.
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Nature Publishing Group
2017-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02322-5 |
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doaj-cb128c406cd844578138ccf113906e622021-05-11T07:31:45ZengNature Publishing GroupNature Communications2041-17232017-12-018111810.1038/s41467-017-02322-5Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1Julia Pose-Utrilla0Lucía García-Guerra1Ana Del Puerto2Abraham Martín3Jerónimo Jurado-Arjona4Noelia S. De León-Reyes5Andrea Gamir-Morralla6Álvaro Sebastián-Serrano7Mónica García-Gallo8Leonor Kremer9Jens Fielitz10Christofer Ireson11Mª José Pérez-Álvarez12Isidro Ferrer13Félix Hernández14Jesús Ávila15Marina Lasa16Miguel R. Campanero17Teresa Iglesias18Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Experimental Molecular Imaging (Molecular Imaging Unit), CIC biomaGUNECIBERNED, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos IIIInstituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Protein Tools Unit, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Científicas (CSIC)Protein Tools Unit, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Científicas (CSIC)Experimental and Clinical Research Center (ECRC), Charité-Universitätsmedizin, Max-Delbrück-Center (MDC) for Molecular Medicine in the Helmholtz AssociationCancer Research TechnologyCIBERNED, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos IIICIBERNED, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos IIICIBERNED, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos IIICIBERNED, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos IIIInstituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM)Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can be neuroprotective.https://doi.org/10.1038/s41467-017-02322-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Julia Pose-Utrilla Lucía García-Guerra Ana Del Puerto Abraham Martín Jerónimo Jurado-Arjona Noelia S. De León-Reyes Andrea Gamir-Morralla Álvaro Sebastián-Serrano Mónica García-Gallo Leonor Kremer Jens Fielitz Christofer Ireson Mª José Pérez-Álvarez Isidro Ferrer Félix Hernández Jesús Ávila Marina Lasa Miguel R. Campanero Teresa Iglesias |
| spellingShingle |
Julia Pose-Utrilla Lucía García-Guerra Ana Del Puerto Abraham Martín Jerónimo Jurado-Arjona Noelia S. De León-Reyes Andrea Gamir-Morralla Álvaro Sebastián-Serrano Mónica García-Gallo Leonor Kremer Jens Fielitz Christofer Ireson Mª José Pérez-Álvarez Isidro Ferrer Félix Hernández Jesús Ávila Marina Lasa Miguel R. Campanero Teresa Iglesias Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 Nature Communications |
| author_facet |
Julia Pose-Utrilla Lucía García-Guerra Ana Del Puerto Abraham Martín Jerónimo Jurado-Arjona Noelia S. De León-Reyes Andrea Gamir-Morralla Álvaro Sebastián-Serrano Mónica García-Gallo Leonor Kremer Jens Fielitz Christofer Ireson Mª José Pérez-Álvarez Isidro Ferrer Félix Hernández Jesús Ávila Marina Lasa Miguel R. Campanero Teresa Iglesias |
| author_sort |
Julia Pose-Utrilla |
| title |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_short |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_full |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_fullStr |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_full_unstemmed |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_sort |
excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by pkd1 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-12-01 |
| description |
Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can be neuroprotective. |
| url |
https://doi.org/10.1038/s41467-017-02322-5 |
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