The fraction of sensitization among lung transplant recipients in a transplant center in Japan
Abstract Background Anti-human leukocyte antigen (HLA) antibody testing was approved by the Japanese government in 2018. As such, there was no longitudinal data regarding the HLA-sensitization of lung transplant (LTX) patients in Japan. We therefore set out to measure anti-HLA antibodies from all ou...
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doaj-cb1eead47a3f412cbebd8c68ee0c5aac2020-11-25T03:55:47ZengBMCBMC Pulmonary Medicine1471-24662020-10-012011810.1186/s12890-020-01299-0The fraction of sensitization among lung transplant recipients in a transplant center in JapanSakiko Kumata0Takashi Hirama1Yui Watanabe2Hisashi Oishi3Hiromichi Niikawa4Miki Akiba5Jussi Tikkanen6Yoshinori Okada7Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku UniversityDivision of Organ Transplantation, Tohoku University HospitalMulti-Organ Transplant Program, Toronto General HospitalDepartment of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku UniversityAbstract Background Anti-human leukocyte antigen (HLA) antibody testing was approved by the Japanese government in 2018. As such, there was no longitudinal data regarding the HLA-sensitization of lung transplant (LTX) patients in Japan. We therefore set out to measure anti-HLA antibodies from all our LTX patients during their annual follow-up to characterize the sensitization status in the Japanese population. Methods The cross-sectional study was conducted for consecutive LTX recipients who underwent transplantation from January 2000 to January 2020 at Tohoku University Hospital (TUH). The serum from the recipients was screened for anti-HLA antibody with the panel-reactive assay (PRA) and the donor-specific antibodies (DSA). Results Sensitization was reviewed in 93 LTX recipients, showing 23 positive (24.7%) and 70 negative (75.3%) PRA. More sensitized recipients were found in recent transplantations (60.9% (14/23), ≤5 years post LTX) than in older transplantations (17.4% (4/23), 5–10 years or 21.7% (5/23), ≥10 years post LTX) (p = 0.04). Even fewer recipients had DSA (5.4%, 5/93), among whom 4/5 (80%) were recently transplanted. Conclusion The rate of PRA positive LTX recipients in our population was lower compared with those in previous reports from US and Europe. More sensitized LTRs were found in recent transplantations than the older cohort, and DSA was identified primarily in the recent recipients. Due to several limitations, it is still unclear whether the sensitization would be related the development of CLAD or survival, yet this study would be fundamental to the future anti-HLA body study in Japanese population.http://link.springer.com/article/10.1186/s12890-020-01299-0Lung transplantPanel-reactive assay (PRA)Donor-specific antibodies (DSA)JapanHuman leukocyte antigen (HLA)Chronic lung allograft dysfunction (CLAD) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sakiko Kumata Takashi Hirama Yui Watanabe Hisashi Oishi Hiromichi Niikawa Miki Akiba Jussi Tikkanen Yoshinori Okada |
spellingShingle |
Sakiko Kumata Takashi Hirama Yui Watanabe Hisashi Oishi Hiromichi Niikawa Miki Akiba Jussi Tikkanen Yoshinori Okada The fraction of sensitization among lung transplant recipients in a transplant center in Japan BMC Pulmonary Medicine Lung transplant Panel-reactive assay (PRA) Donor-specific antibodies (DSA) Japan Human leukocyte antigen (HLA) Chronic lung allograft dysfunction (CLAD) |
author_facet |
Sakiko Kumata Takashi Hirama Yui Watanabe Hisashi Oishi Hiromichi Niikawa Miki Akiba Jussi Tikkanen Yoshinori Okada |
author_sort |
Sakiko Kumata |
title |
The fraction of sensitization among lung transplant recipients in a transplant center in Japan |
title_short |
The fraction of sensitization among lung transplant recipients in a transplant center in Japan |
title_full |
The fraction of sensitization among lung transplant recipients in a transplant center in Japan |
title_fullStr |
The fraction of sensitization among lung transplant recipients in a transplant center in Japan |
title_full_unstemmed |
The fraction of sensitization among lung transplant recipients in a transplant center in Japan |
title_sort |
fraction of sensitization among lung transplant recipients in a transplant center in japan |
publisher |
BMC |
series |
BMC Pulmonary Medicine |
issn |
1471-2466 |
publishDate |
2020-10-01 |
description |
Abstract Background Anti-human leukocyte antigen (HLA) antibody testing was approved by the Japanese government in 2018. As such, there was no longitudinal data regarding the HLA-sensitization of lung transplant (LTX) patients in Japan. We therefore set out to measure anti-HLA antibodies from all our LTX patients during their annual follow-up to characterize the sensitization status in the Japanese population. Methods The cross-sectional study was conducted for consecutive LTX recipients who underwent transplantation from January 2000 to January 2020 at Tohoku University Hospital (TUH). The serum from the recipients was screened for anti-HLA antibody with the panel-reactive assay (PRA) and the donor-specific antibodies (DSA). Results Sensitization was reviewed in 93 LTX recipients, showing 23 positive (24.7%) and 70 negative (75.3%) PRA. More sensitized recipients were found in recent transplantations (60.9% (14/23), ≤5 years post LTX) than in older transplantations (17.4% (4/23), 5–10 years or 21.7% (5/23), ≥10 years post LTX) (p = 0.04). Even fewer recipients had DSA (5.4%, 5/93), among whom 4/5 (80%) were recently transplanted. Conclusion The rate of PRA positive LTX recipients in our population was lower compared with those in previous reports from US and Europe. More sensitized LTRs were found in recent transplantations than the older cohort, and DSA was identified primarily in the recent recipients. Due to several limitations, it is still unclear whether the sensitization would be related the development of CLAD or survival, yet this study would be fundamental to the future anti-HLA body study in Japanese population. |
topic |
Lung transplant Panel-reactive assay (PRA) Donor-specific antibodies (DSA) Japan Human leukocyte antigen (HLA) Chronic lung allograft dysfunction (CLAD) |
url |
http://link.springer.com/article/10.1186/s12890-020-01299-0 |
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