A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins. Despite extant homology between certain subunits, the degree of structural and organizational overlap between budding yeast and metazoan ORC...

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Bibliographic Details
Main Authors: Franziska Bleichert, Maxim Balasov, Igor Chesnokov, Eva Nogales, Michael R Botchan, James M Berger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-10-01
Series:eLife
Subjects:
ORC
Meier-Gorlin syndrome
DNA replication
origin recognition complex
origin licensing
Online Access:https://elifesciences.org/articles/00882

Internet

https://elifesciences.org/articles/00882

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