Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma
Objective: Programmed cell death ligand 1 (PD-L1) and mammalian target of rapamycin (mTOR) are key players in host immune evasion and oncogenic activation, respectively. Evidence of the prognostic role in oral squamous cell carcinoma (OSCC) is conflicting. This study examined the associations of PD-...
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doaj-cb287b1461e8464d916a0d87b091464e2020-11-25T04:03:52ZengPrince of Songkla UniversityJournal of Health Science and Medical Research (JHSMR)2586-99812630-05592020-06-0138425526610.31584/jhsmr.2020745758Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell CarcinomaNattinee Charoen0Kitti Jantharapattana1Paramee Thongsuksai2Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Objective: Programmed cell death ligand 1 (PD-L1) and mammalian target of rapamycin (mTOR) are key players in host immune evasion and oncogenic activation, respectively. Evidence of the prognostic role in oral squamous cell carcinoma (OSCC) is conflicting. This study examined the associations of PD-L1 and mTOR expression with 5-year overall survival in OSCC patients. Material and Methods: The expressions of PD-L1 and mTOR proteins were immunohistochemically evaluated on tissue microarrays of 191 patients with OSCC who were treated by surgery at Songklanagarind Hospital, Thailand from 2008 to 2011. Cox regression analysis was used to determine independent prognostic factors. Results: PD-L1 expression was observed in 14.1% of cases while mTOR expression was present in 74.3% of cases. Females were more likely to have tumors with PD-L1 (p-value=0.007) and mTOR expressions (p-value=0.003) than males. In addition, lower clinical stage and well differentiated tumor are more likely to have mTOR expression (p-value= 0.038 and p-value<0.001, respectively). Cox regression analysis showed that age, tumor stage, nodal stage, combined surgical treatment with radiation or chemoradiation therapy, surgical margin status, PD-L1 expression and mTOR expression are independent prognostic factors. High PD-L1 expression (hazard ratio (HR) 3.14, 95% confidence interval (CI), 1.26–7.79) and high mTOR expression (HR 1.69, 95% CI, 1.00–2.84) are strong predictors of poor outcome. Conclusion: A proportion of OSCC expressed PD-L1 and mTOR proteins. Expression of PD-L1 and mTOR proteins are strong prognostic factors of OSCC.https://www.jhsmr.org/index.php/jhsmr/article/view/745oral squamous cell carcinomapd-l1, mtorprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nattinee Charoen Kitti Jantharapattana Paramee Thongsuksai |
spellingShingle |
Nattinee Charoen Kitti Jantharapattana Paramee Thongsuksai Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma Journal of Health Science and Medical Research (JHSMR) oral squamous cell carcinoma pd-l1, mtor prognosis |
author_facet |
Nattinee Charoen Kitti Jantharapattana Paramee Thongsuksai |
author_sort |
Nattinee Charoen |
title |
Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma |
title_short |
Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma |
title_full |
Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma |
title_fullStr |
Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma |
title_full_unstemmed |
Prognostic Significance of PD-L1 and mTOR Expression in Oral Squamous Cell Carcinoma |
title_sort |
prognostic significance of pd-l1 and mtor expression in oral squamous cell carcinoma |
publisher |
Prince of Songkla University |
series |
Journal of Health Science and Medical Research (JHSMR) |
issn |
2586-9981 2630-0559 |
publishDate |
2020-06-01 |
description |
Objective: Programmed cell death ligand 1 (PD-L1) and mammalian target of rapamycin (mTOR) are key players in host immune evasion and oncogenic activation, respectively. Evidence of the prognostic role in oral squamous cell carcinoma (OSCC) is conflicting. This study examined the associations of PD-L1 and mTOR expression with 5-year overall survival in OSCC patients.
Material and Methods: The expressions of PD-L1 and mTOR proteins were immunohistochemically evaluated on tissue microarrays of 191 patients with OSCC who were treated by surgery at Songklanagarind Hospital, Thailand from 2008 to 2011. Cox regression analysis was used to determine independent prognostic factors.
Results: PD-L1 expression was observed in 14.1% of cases while mTOR expression was present in 74.3% of cases. Females were more likely to have tumors with PD-L1 (p-value=0.007) and mTOR expressions (p-value=0.003) than males. In addition, lower clinical stage and well differentiated tumor are more likely to have mTOR expression (p-value= 0.038 and p-value<0.001, respectively). Cox regression analysis showed that age, tumor stage, nodal stage, combined surgical treatment with radiation or chemoradiation therapy, surgical margin status, PD-L1 expression and mTOR expression are independent prognostic factors. High PD-L1 expression (hazard ratio (HR) 3.14, 95% confidence interval (CI), 1.26–7.79) and high mTOR expression (HR 1.69, 95% CI, 1.00–2.84) are strong predictors of poor outcome.
Conclusion: A proportion of OSCC expressed PD-L1 and mTOR proteins. Expression of PD-L1 and mTOR proteins are strong prognostic factors of OSCC. |
topic |
oral squamous cell carcinoma pd-l1, mtor prognosis |
url |
https://www.jhsmr.org/index.php/jhsmr/article/view/745 |
work_keys_str_mv |
AT nattineecharoen prognosticsignificanceofpdl1andmtorexpressioninoralsquamouscellcarcinoma AT kittijantharapattana prognosticsignificanceofpdl1andmtorexpressioninoralsquamouscellcarcinoma AT parameethongsuksai prognosticsignificanceofpdl1andmtorexpressioninoralsquamouscellcarcinoma |
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