Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling

Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling

Background: Trauma often co-occurs with cardiac arrest and hemorrhagic shock. Skin and muscle injuries often lead to significant inflammation in the affected tissue. The primary mechanism by which inflammation is initiated, sustained, and terminated is cytokine-mediated immune signaling, but this si...

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Bibliographic Details
Main Authors: Ravi eStarzl, Dolores eWolfram, Ruben eZamora, Bahiyyah eJefferson, Derek eBarclay, Chien eHo, Vijay S Gorantla, Gerald eBrandacher, Stefan eSchneeberger, W.P. Andrew eLee, Jaime eCarbonell, Yoram eVodovotz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
Cytokines
Inflammasome
Cytokines and inflammation
Immunoregulation
transplant tolerance
Composite Tissue Allotransplantation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00587/full

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