Gallbladder Radiation Protection in SIRT—Quantitative Anatomical Study of Hepatic Vasculature

• Main Authors: Piotr Piasecki, Krzysztof Brzozowski, Piotr Ziecina, Marek Wierzbicki, Anna Budzynska, Andrzej Mazurek, Miroslaw Dziuk, Maciej Maciak, Edward Iller, Jerzy Narloch
• Format: Article
• Language: English
• Published: MDPI AG 2019-09-01
• Series: Journal of Clinical Medicine
• Subjects: SIRT; gallbladder radiation; vascular anatomy; hepatic artery; cystic artery; extrahepatic leaking
• Online Access: https://www.mdpi.com/2077-0383/8/10/1531

<b>Introduction:</b> This study was designed to assess quantitatively a safe position of the microcatheter during the SIRT (Selective Internal Radiation Therapy) procedure, in order to minimize the risk of non-target spheres leaking. <b>Materials and Methods:</b> Retrospective analysis of the distance of the tip of the microcatheter from coiled or patent non-target arteries was measured during ^99mTc-MAA work-up procedure. Frequency of extrahepatic leaking during work-up and SIRT procedures was evaluated. <b>Results:</b> There were 85 patients who underwent 98 work-up procedures. There were 64 radioembolizations. There were 44 gastroduodenal, 51 right gastric, and 54 cystic artery embolizations performed. Extrahepatic ^99mTc-MAA leaking was observed in 33 cases: 16 to gallbladder, four to a gastric wall, nine to the duodenum, one to the intestinal wall, and three to the abdominal wall. Leak in ^99mTc-MAA was also related to the presence of additional arteries (<i>p</i> = 0.009). There were 34 proximal and 31 distal to cystic artery ^99mTc-MAA injections resulting in 12 vs. four leaks, respectively (<i>p</i> = 0.039, RR-2.5). Mean distance of the tip of the microcatheter from the origin of the cystic artery was 20 mm (minimum of 2.1 mm and maximum of 53 mm) proximally and 10 mm (minimum 1 mm and maximum 51 mm) distally (ns). <b>Conclusions:</b> Leaking in ^99mTc-MAA (^99mTc - labelled macroaggregated albumin) was related to the presence of additional arteries. Regardless of cystic artery embolization, it is 2.5 times safer to inject microspheres distal to its origin, compared to proximal injection. Cystic artery origin relative to the right hepatic artery division usually necessitates embolization of the former.