Efficient Synthesis of the Lewis A Tandem Repeat

Efficient Synthesis of the Lewis A Tandem Repeat

The convergent synthesis of the Lewis A (Lea) tandem repeat is described. The Lea tandem repeat is a carbohydrate ligand for a mannose binding protein that shows potent inhibitory activity against carcinoma growth. The Lea unit, {β-d-Gal-(1→3)-[α-l-Fuc-(1→4)]-β-d-GlcNAc}, was synthesized by stereose...

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Bibliographic Details
Main Authors: Daisuke Kobayashi, Akiharu Ueki, Tomoya Yamaji, Kazuya Nagao, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Hideharu Ishida
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
Lewis A tandem repeat
convergent synthesis
sugar-binding protein
Online Access:http://www.mdpi.com/1420-3049/21/5/614

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