A Case of Rare Cutaneous Metastasis from Advanced Pancreatic Cancer

• Main Authors: Hiroyuki Ito, Takuma Tajiri, Shin-ichiro Hiraiwa, Tomoko Sugiyama, Ayano Ito, Yoshimasa Shinma, Motoki Kaneko, Kazuya Anzai, Shingo Tsuda, Hitoshi Ichikawa, Junko Nagata, Seiichiro Kojima, Norihito Watanabe
• Format: Article
• Language: English
• Published: Karger Publishers 2020-01-01
• Series: Case Reports in Oncology
• Subjects: pancreatic cancer; cutaneous metastasis; bone metastasis
• Online Access: https://www.karger.com/Article/FullText/505322

A 71-year-old woman presented to a nearby hospital with an occipital scalp ulcer with exudate. Thoracoabdominal enhanced computed tomography (CT) was performed due to suspected cancer. The imaging results showed tumors in the pancreatic tail and at multiple sites in the lung, whereupon she was referred to our hospital for further investigation. Histological analysis of the occipital scalp ulcer and the pancreatic tumor led to the diagnosis of pancreatic adenocarcinoma with cutaneous metastasis and multiple lung metastases. Combination chemotherapy (gemcitabine and nab-paclitaxel) was started, and about 4 months later the patient experienced right lower back pain. Abdominal CT showed partial sclerosis of the right iliac bone and multiple spinal lesions, which were diagnosed as multiple bone metastases. Narcotic analgesia was started for the right lower back pain. Since then, FOLFIRINOX has been introduced as second-line chemotherapy against tumor growth, and treatment has been ongoing for 10 months since the initial chemotherapy. Pancreatic cancer is a rapidly growing cancer and can show early metastasis to other organs, lymph node metastasis, and peritoneal dissemination; therefore, the prognosis of pancreatic cancer is very poor. Cutaneous metastasis from pancreatic cancer is rare, and only a few cases have been reported. Here, we report an unusual case of pancreatic adenocarcinoma with cutaneous metastasis and multiple lung and bone metastases.