Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.

Bibliographic Details
Main Authors:	Matteo Spinelli, Salvatore Fusco, Marco Mainardi, Federico Scala, Francesca Natale, Rosita Lapenta, Andrea Mattera, Marco Rinaudo, Domenica Donatella Li Puma, Cristian Ripoli, Alfonso Grassi, Marcello D’Ascenzo, Claudio Grassi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02221-9

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spelling	doaj-cb4640a300fa422e8b1d52b272e63d1d2021-05-11T07:25:14ZengNature Publishing GroupNature Communications2041-17232017-12-018111410.1038/s41467-017-02221-9Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3aMatteo Spinelli0Salvatore Fusco1Marco Mainardi2Federico Scala3Francesca Natale4Rosita Lapenta5Andrea Mattera6Marco Rinaudo7Domenica Donatella Li Puma8Cristian Ripoli9Alfonso Grassi10Marcello D’Ascenzo11Claudio Grassi12Institute of Human Physiology, Università Cattolica Medical SchoolInstitute of Human Physiology, Università Cattolica Medical SchoolInstitute of Human Physiology, Università Cattolica Medical SchoolInstitute of Human Physiology, Università Cattolica Medical SchoolInstitute of Human Physiology, Università Cattolica Medical SchoolDepartment of Chemistry and Biology, University of SalernoInstitute of Human Physiology, Università Cattolica Medical SchoolInstitute of Human Physiology, Università Cattolica Medical SchoolInstitute of Human Physiology, Università Cattolica Medical SchoolInstitute of Human Physiology, Università Cattolica Medical SchoolDepartment of Chemistry and Biology, University of SalernoInstitute of Human Physiology, Università Cattolica Medical SchoolInstitute of Human Physiology, Università Cattolica Medical SchoolMetabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.https://doi.org/10.1038/s41467-017-02221-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Matteo Spinelli Salvatore Fusco Marco Mainardi Federico Scala Francesca Natale Rosita Lapenta Andrea Mattera Marco Rinaudo Domenica Donatella Li Puma Cristian Ripoli Alfonso Grassi Marcello D’Ascenzo Claudio Grassi
spellingShingle	Matteo Spinelli Salvatore Fusco Marco Mainardi Federico Scala Francesca Natale Rosita Lapenta Andrea Mattera Marco Rinaudo Domenica Donatella Li Puma Cristian Ripoli Alfonso Grassi Marcello D’Ascenzo Claudio Grassi Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a Nature Communications
author_facet	Matteo Spinelli Salvatore Fusco Marco Mainardi Federico Scala Francesca Natale Rosita Lapenta Andrea Mattera Marco Rinaudo Domenica Donatella Li Puma Cristian Ripoli Alfonso Grassi Marcello D’Ascenzo Claudio Grassi
author_sort	Matteo Spinelli
title	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_short	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_full	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_fullStr	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_full_unstemmed	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_sort	brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing glua1 palmitoylation through foxo3a
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.
url	https://doi.org/10.1038/s41467-017-02221-9
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Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

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