Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression

Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression

N–6 polyunsaturated fatty acids (PUFA) suppress hepatic and adipocyte de novo lipogenesis by inhibiting the transcription of genes encoding key lipogenic proteins. In cultured 3T3-L1 adipocytes, arachidonic acid (20:4,n–6) suppression of lipogenic gene expression requires cyclooxygenase (COX) activi...

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Bibliographic Details
Main Authors: Michelle K. Mater, Annette P. Thelen, Donald B. Jump
Format: Article
Language:English
Published: Elsevier 1999-06-01
Series:Journal of Lipid Research
Subjects:
S14 protein
fatty acid synthase
l-pyruvate kinase
cyclooxygenase
gene transcription
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335082

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http://www.sciencedirect.com/science/article/pii/S0022227520335082

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