Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities...

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Bibliographic Details
Main Authors: Johny Wysllas de Freitas Oliveira, Hugo Alexandre Oliveira Rocha, Wendy Marina Toscano Queiroz de Medeiros, Marcelo Sousa Silva
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/24/15/2806
Description
Summary:Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.
ISSN:1420-3049