Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological
Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities...
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2019-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/15/2806 |
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doaj-cb539dfea7dd49f3ad8e57c34d01e4b82020-11-25T00:37:17ZengMDPI AGMolecules1420-30492019-08-012415280610.3390/molecules24152806molecules24152806Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and BiologicalJohny Wysllas de Freitas Oliveira0Hugo Alexandre Oliveira Rocha1Wendy Marina Toscano Queiroz de Medeiros2Marcelo Sousa Silva3Laboratório de Imunoparasitologia, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal 59012-570, BrazilPrograma de Pós-graduação em Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal 59012-570, BrazilLaboratório de Imunoparasitologia, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal 59012-570, BrazilLaboratório de Imunoparasitologia, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal 59012-570, BrazilDithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.https://www.mdpi.com/1420-3049/24/15/2806dithiocarbamatesDETCantiparasitic activity<i>Trypanosomatids</i>Chagas diseaseleishmaniasisAfrican trypanosomiasis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Johny Wysllas de Freitas Oliveira Hugo Alexandre Oliveira Rocha Wendy Marina Toscano Queiroz de Medeiros Marcelo Sousa Silva |
| spellingShingle |
Johny Wysllas de Freitas Oliveira Hugo Alexandre Oliveira Rocha Wendy Marina Toscano Queiroz de Medeiros Marcelo Sousa Silva Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological Molecules dithiocarbamates DETC antiparasitic activity <i>Trypanosomatids</i> Chagas disease leishmaniasis African trypanosomiasis |
| author_facet |
Johny Wysllas de Freitas Oliveira Hugo Alexandre Oliveira Rocha Wendy Marina Toscano Queiroz de Medeiros Marcelo Sousa Silva |
| author_sort |
Johny Wysllas de Freitas Oliveira |
| title |
Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological |
| title_short |
Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological |
| title_full |
Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological |
| title_fullStr |
Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological |
| title_full_unstemmed |
Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological |
| title_sort |
application of dithiocarbamates as potential new antitrypanosomatids-drugs: approach chemistry, functional and biological |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2019-08-01 |
| description |
Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis. |
| topic |
dithiocarbamates DETC antiparasitic activity <i>Trypanosomatids</i> Chagas disease leishmaniasis African trypanosomiasis |
| url |
https://www.mdpi.com/1420-3049/24/15/2806 |
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