Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America.
Triatomines are the vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Although Triatoma and Rhodnius are the most-studied vector genera, other triatomines, such as Panstrongylus, also transmit T. cruzi, creating new epidemiological scenarios. Panstrongylus has at least 13 report...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0223963 |
id |
doaj-cb54058fdc7c4739baf50ebacd4d2c65 |
---|---|
record_format |
Article |
spelling |
doaj-cb54058fdc7c4739baf50ebacd4d2c652021-03-03T21:11:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011410e022396310.1371/journal.pone.0223963Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America.Valentina Caicedo-GarzónFabian C Salgado-RoaMelissa Sánchez-HerreraCarolina HernándezLuisa María Arias-GiraldoLineth GarcíaGustavo VallejoOmar CantilloCatalina TovarJoao Aristeu da RosaHernán J CarrascoMaikell SegoviaCamilo SalazarJuan David RamírezTriatomines are the vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Although Triatoma and Rhodnius are the most-studied vector genera, other triatomines, such as Panstrongylus, also transmit T. cruzi, creating new epidemiological scenarios. Panstrongylus has at least 13 reported species but there is limited information about its intraspecific genetic variation and patterns of diversification. Here, we begin to fill this gap by studying populations of P. geniculatus from Colombia and Venezuela and including other epidemiologically important species from the region. We examined the pattern of diversification of P. geniculatus in Colombia using mitochondrial and nuclear ribosomal data. Genetic diversity and differentiation were calculated within and among populations of P. geniculatus. Moreover, we constructed maximum likelihood and Bayesian inference phylogenies and haplotype networks using P. geniculatus and other species from the genus (P. megistus, P. lignarius, P. lutzi, P. tupynambai, P. chinai, P. rufotuberculatus and P. howardi). Using a coalescence framework, we also dated the P. geniculatus lineages. The total evidence tree showed that P. geniculatus is a monophyletic species, with four clades that are concordant with its geographic distribution and are partly explained by the Andes orogeny. However, other factors, including anthropogenic and eco-epidemiological effects must be investigated to explain the existence of recent geographic P. geniculatus lineages. The epidemiological dynamics in structured vector populations, such as those found here, warrant further investigation. Extending our knowledge of P. geniculatus is necessary for the accurate development of effective strategies for the control of Chagas disease vectors.https://doi.org/10.1371/journal.pone.0223963 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Valentina Caicedo-Garzón Fabian C Salgado-Roa Melissa Sánchez-Herrera Carolina Hernández Luisa María Arias-Giraldo Lineth García Gustavo Vallejo Omar Cantillo Catalina Tovar Joao Aristeu da Rosa Hernán J Carrasco Maikell Segovia Camilo Salazar Juan David Ramírez |
spellingShingle |
Valentina Caicedo-Garzón Fabian C Salgado-Roa Melissa Sánchez-Herrera Carolina Hernández Luisa María Arias-Giraldo Lineth García Gustavo Vallejo Omar Cantillo Catalina Tovar Joao Aristeu da Rosa Hernán J Carrasco Maikell Segovia Camilo Salazar Juan David Ramírez Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America. PLoS ONE |
author_facet |
Valentina Caicedo-Garzón Fabian C Salgado-Roa Melissa Sánchez-Herrera Carolina Hernández Luisa María Arias-Giraldo Lineth García Gustavo Vallejo Omar Cantillo Catalina Tovar Joao Aristeu da Rosa Hernán J Carrasco Maikell Segovia Camilo Salazar Juan David Ramírez |
author_sort |
Valentina Caicedo-Garzón |
title |
Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America. |
title_short |
Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America. |
title_full |
Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America. |
title_fullStr |
Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America. |
title_full_unstemmed |
Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America. |
title_sort |
genetic diversification of panstrongylus geniculatus (reduviidae: triatominae) in northern south america. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2019-01-01 |
description |
Triatomines are the vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Although Triatoma and Rhodnius are the most-studied vector genera, other triatomines, such as Panstrongylus, also transmit T. cruzi, creating new epidemiological scenarios. Panstrongylus has at least 13 reported species but there is limited information about its intraspecific genetic variation and patterns of diversification. Here, we begin to fill this gap by studying populations of P. geniculatus from Colombia and Venezuela and including other epidemiologically important species from the region. We examined the pattern of diversification of P. geniculatus in Colombia using mitochondrial and nuclear ribosomal data. Genetic diversity and differentiation were calculated within and among populations of P. geniculatus. Moreover, we constructed maximum likelihood and Bayesian inference phylogenies and haplotype networks using P. geniculatus and other species from the genus (P. megistus, P. lignarius, P. lutzi, P. tupynambai, P. chinai, P. rufotuberculatus and P. howardi). Using a coalescence framework, we also dated the P. geniculatus lineages. The total evidence tree showed that P. geniculatus is a monophyletic species, with four clades that are concordant with its geographic distribution and are partly explained by the Andes orogeny. However, other factors, including anthropogenic and eco-epidemiological effects must be investigated to explain the existence of recent geographic P. geniculatus lineages. The epidemiological dynamics in structured vector populations, such as those found here, warrant further investigation. Extending our knowledge of P. geniculatus is necessary for the accurate development of effective strategies for the control of Chagas disease vectors. |
url |
https://doi.org/10.1371/journal.pone.0223963 |
work_keys_str_mv |
AT valentinacaicedogarzon geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT fabiancsalgadoroa geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT melissasanchezherrera geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT carolinahernandez geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT luisamariaariasgiraldo geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT linethgarcia geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT gustavovallejo geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT omarcantillo geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT catalinatovar geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT joaoaristeudarosa geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT hernanjcarrasco geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT maikellsegovia geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT camilosalazar geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica AT juandavidramirez geneticdiversificationofpanstrongylusgeniculatusreduviidaetriatominaeinnorthernsouthamerica |
_version_ |
1714818352358096896 |