Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum

Plasmodium has evolved high genetic diversity in var genes, which encode for the major blood-stage antigen. Here, He et al. show how immune selection shapes the var gene repertoire in both simulated systems and a population in Ghana, by using neutral models and genetic similarity networks.

Bibliographic Details
Main Authors:	Qixin He, Shai Pilosof, Kathryn E. Tiedje, Shazia Ruybal-Pesántez, Yael Artzy-Randrup, Edward B. Baskerville, Karen P. Day, Mercedes Pascual
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04219-3

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spelling	doaj-cb6f3ee99e554b4780c6cb642bf2ee642021-05-11T09:32:55ZengNature Publishing GroupNature Communications2041-17232018-05-019111210.1038/s41467-018-04219-3Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparumQixin He0Shai Pilosof1Kathryn E. Tiedje2Shazia Ruybal-Pesántez3Yael Artzy-Randrup4Edward B. Baskerville5Karen P. Day6Mercedes Pascual7Department of Ecology and Evolution, University of ChicagoDepartment of Ecology and Evolution, University of ChicagoSchool of BioSciences, Bio21 Institute/University of MelbourneSchool of BioSciences, Bio21 Institute/University of MelbourneDepartment of Theoretical and Computational Ecology, IBED, and Institute of Advanced Study, University of AmsterdamDepartment of Ecology and Evolution, University of ChicagoSchool of BioSciences, Bio21 Institute/University of MelbourneDepartment of Ecology and Evolution, University of ChicagoPlasmodium has evolved high genetic diversity in var genes, which encode for the major blood-stage antigen. Here, He et al. show how immune selection shapes the var gene repertoire in both simulated systems and a population in Ghana, by using neutral models and genetic similarity networks.https://doi.org/10.1038/s41467-018-04219-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qixin He Shai Pilosof Kathryn E. Tiedje Shazia Ruybal-Pesántez Yael Artzy-Randrup Edward B. Baskerville Karen P. Day Mercedes Pascual
spellingShingle	Qixin He Shai Pilosof Kathryn E. Tiedje Shazia Ruybal-Pesántez Yael Artzy-Randrup Edward B. Baskerville Karen P. Day Mercedes Pascual Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum Nature Communications
author_facet	Qixin He Shai Pilosof Kathryn E. Tiedje Shazia Ruybal-Pesántez Yael Artzy-Randrup Edward B. Baskerville Karen P. Day Mercedes Pascual
author_sort	Qixin He
title	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_short	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_full	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_fullStr	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_full_unstemmed	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_sort	networks of genetic similarity reveal non-neutral processes shape strain structure in plasmodium falciparum
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-05-01
description	Plasmodium has evolved high genetic diversity in var genes, which encode for the major blood-stage antigen. Here, He et al. show how immune selection shapes the var gene repertoire in both simulated systems and a population in Ghana, by using neutral models and genetic similarity networks.
url	https://doi.org/10.1038/s41467-018-04219-3
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Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum

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