Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
Plasmodium has evolved high genetic diversity in var genes, which encode for the major blood-stage antigen. Here, He et al. show how immune selection shapes the var gene repertoire in both simulated systems and a population in Ghana, by using neutral models and genetic similarity networks.
Main Authors: | Qixin He, Shai Pilosof, Kathryn E. Tiedje, Shazia Ruybal-Pesántez, Yael Artzy-Randrup, Edward B. Baskerville, Karen P. Day, Mercedes Pascual |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-05-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04219-3 |
Similar Items
-
Competition for hosts modulates vast antigenic diversity to generate persistent strain structure in Plasmodium falciparum.
by: Shai Pilosof, et al.
Published: (2019-06-01) -
Frequency-Dependent Competition Between Strains Imparts Persistence to Perturbations in a Model of Plasmodium falciparum Malaria Transmission
by: Qixin He, et al.
Published: (2021-05-01) -
Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum
by: Yael Artzy-Randrup, et al.
Published: (2012-12-01) -
Transmission intensity and drug resistance in malaria population dynamics: implications for climate change.
by: Yael Artzy-Randrup, et al.
Published: (2010-10-01) -
Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents.
by: Gerry Tonkin-Hill, et al.
Published: (2021-02-01)