The NMN Module Conducts Nodule Number Orchestra
Legumes control nodule number through nodulation and autoregulation of nodulation (AON) pathways. Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module, which consists of two positive regulators, GmNINa and miR172c, and...
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doaj-cb6f4d915450487ca992261c340562342020-11-25T01:25:55ZengElsevieriScience2589-00422020-02-01232The NMN Module Conducts Nodule Number OrchestraZhijuan Wang0Lixiang Wang1Yongliang Wang2Xia Li3State Key Laboratory of Agricultural Microbiology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. ChinaState Key Laboratory of Agricultural Microbiology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China; Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, Kaifeng, ChinaState Key Laboratory of Agricultural Microbiology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. ChinaState Key Laboratory of Agricultural Microbiology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China; Corresponding authorLegumes control nodule number through nodulation and autoregulation of nodulation (AON) pathways. Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module, which consists of two positive regulators, GmNINa and miR172c, and a suppressor, NNC1, integrates both pathways. GmNINa activates miR172c to downregulate NNC1, leading to nodulation, while NNC1 inhibits miR172c expression, forming a negative feedback loop. GmNINa and NNC1 interact with each other and antagonistically fine-tune GmRIC1/RIC2 expression, turning AON on and off. Conversely, activation of AON inhibits GmNINa and miR172c expression, thereby reducing their inhibitory effects on NNC1 to attenuate both nodulation signaling and AON. The NMN module functions not only as an “accelerator” of the nodulation signal to promote nodulation but also as a “brake” on the signal by activating AON to orchestrate nodule number. : Plant Biology; Interaction of Plants with Organisms; Plant Genetics Subject Areas: Plant Biology, Interaction of Plants with Organisms, Plant Geneticshttp://www.sciencedirect.com/science/article/pii/S2589004220300080 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhijuan Wang Lixiang Wang Yongliang Wang Xia Li |
spellingShingle |
Zhijuan Wang Lixiang Wang Yongliang Wang Xia Li The NMN Module Conducts Nodule Number Orchestra iScience |
author_facet |
Zhijuan Wang Lixiang Wang Yongliang Wang Xia Li |
author_sort |
Zhijuan Wang |
title |
The NMN Module Conducts Nodule Number Orchestra |
title_short |
The NMN Module Conducts Nodule Number Orchestra |
title_full |
The NMN Module Conducts Nodule Number Orchestra |
title_fullStr |
The NMN Module Conducts Nodule Number Orchestra |
title_full_unstemmed |
The NMN Module Conducts Nodule Number Orchestra |
title_sort |
nmn module conducts nodule number orchestra |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2020-02-01 |
description |
Legumes control nodule number through nodulation and autoregulation of nodulation (AON) pathways. Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module, which consists of two positive regulators, GmNINa and miR172c, and a suppressor, NNC1, integrates both pathways. GmNINa activates miR172c to downregulate NNC1, leading to nodulation, while NNC1 inhibits miR172c expression, forming a negative feedback loop. GmNINa and NNC1 interact with each other and antagonistically fine-tune GmRIC1/RIC2 expression, turning AON on and off. Conversely, activation of AON inhibits GmNINa and miR172c expression, thereby reducing their inhibitory effects on NNC1 to attenuate both nodulation signaling and AON. The NMN module functions not only as an “accelerator” of the nodulation signal to promote nodulation but also as a “brake” on the signal by activating AON to orchestrate nodule number. : Plant Biology; Interaction of Plants with Organisms; Plant Genetics Subject Areas: Plant Biology, Interaction of Plants with Organisms, Plant Genetics |
url |
http://www.sciencedirect.com/science/article/pii/S2589004220300080 |
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