Breast cancer vaccination comes to age: impacts of bioinformatics
Introduction: Breast cancer, as one of the major causes of cancer death among women, is the central focus of this study. The recent advances in the development and application of computational tools and bioinformatics in the field of immunotherapy of malignancies such as breast cancer have emerged t...
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Tabriz University of Medical Sciences
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doaj-cb7e6257cab84463af91e7c1bad8deb92021-06-22T09:56:38ZengTabriz University of Medical SciencesBioImpacts2228-56602228-56522018-05-018322323510.15171/bi.2018.25bi-17623Breast cancer vaccination comes to age: impacts of bioinformaticsSepideh Parvizpour0Jafar Razmara1Yadollah Omidi2Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Computer Science, Faculty of mathematical Sciences, University of Tabriz, Tabriz, IranResearch Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, IranIntroduction: Breast cancer, as one of the major causes of cancer death among women, is the central focus of this study. The recent advances in the development and application of computational tools and bioinformatics in the field of immunotherapy of malignancies such as breast cancer have emerged the new dominion of immunoinformatics, and therefore, next generation of immunomedicines. Methods: Having reviewed the most recent works on the applications of computational tools, we provide comprehensive insights into the breast cancer incidence and its leading causes as well as immunotherapy approaches and the future trends. Furthermore, we discuss the impacts of bioinformatics on different stages of vaccine design for the breast cancer, which can be used to produce much more efficient vaccines through a rationalized time- and cost-effective in silico approaches prior to conducting costly experiments. Results: The tools can be significantly used for designing the immune system-modulating drugs and vaccines based on in silico approaches prior to in vitro and in vivo experimental evaluations. Application of immunoinformatics in the cancer immunotherapy has shown its success in the pre-clinical models. This success returns back to the impacts of several powerful computational approaches developed during the last decade. Conclusion: Despite the invention of a number of vaccines for the cancer immunotherapy, more computational and clinical trials are required to design much more efficient vaccines against various malignancies, including breast cancer.https://bi.tbzmed.ac.ir/PDF/bi-8-223.pdfbioinformaticscancerepitope-based vaccine designvaccine design |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sepideh Parvizpour Jafar Razmara Yadollah Omidi |
spellingShingle |
Sepideh Parvizpour Jafar Razmara Yadollah Omidi Breast cancer vaccination comes to age: impacts of bioinformatics BioImpacts bioinformatics cancer epitope-based vaccine design vaccine design |
author_facet |
Sepideh Parvizpour Jafar Razmara Yadollah Omidi |
author_sort |
Sepideh Parvizpour |
title |
Breast cancer vaccination comes to age: impacts of bioinformatics |
title_short |
Breast cancer vaccination comes to age: impacts of bioinformatics |
title_full |
Breast cancer vaccination comes to age: impacts of bioinformatics |
title_fullStr |
Breast cancer vaccination comes to age: impacts of bioinformatics |
title_full_unstemmed |
Breast cancer vaccination comes to age: impacts of bioinformatics |
title_sort |
breast cancer vaccination comes to age: impacts of bioinformatics |
publisher |
Tabriz University of Medical Sciences |
series |
BioImpacts |
issn |
2228-5660 2228-5652 |
publishDate |
2018-05-01 |
description |
Introduction: Breast cancer, as one of the major causes of cancer death among women, is the central focus of this study. The recent advances in the development and application of computational tools and bioinformatics in the field of immunotherapy of malignancies such as breast cancer have emerged the new dominion of immunoinformatics, and therefore, next generation of immunomedicines. Methods: Having reviewed the most recent works on the applications of computational tools, we provide comprehensive insights into the breast cancer incidence and its leading causes as well as immunotherapy approaches and the future trends. Furthermore, we discuss the impacts of bioinformatics on different stages of vaccine design for the breast cancer, which can be used to produce much more efficient vaccines through a rationalized time- and cost-effective in silico approaches prior to conducting costly experiments. Results: The tools can be significantly used for designing the immune system-modulating drugs and vaccines based on in silico approaches prior to in vitro and in vivo experimental evaluations. Application of immunoinformatics in the cancer immunotherapy has shown its success in the pre-clinical models. This success returns back to the impacts of several powerful computational approaches developed during the last decade. Conclusion: Despite the invention of a number of vaccines for the cancer immunotherapy, more computational and clinical trials are required to design much more efficient vaccines against various malignancies, including breast cancer. |
topic |
bioinformatics cancer epitope-based vaccine design vaccine design |
url |
https://bi.tbzmed.ac.ir/PDF/bi-8-223.pdf |
work_keys_str_mv |
AT sepidehparvizpour breastcancervaccinationcomestoageimpactsofbioinformatics AT jafarrazmara breastcancervaccinationcomestoageimpactsofbioinformatics AT yadollahomidi breastcancervaccinationcomestoageimpactsofbioinformatics |
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