Pregnancy outcomes after kidney transplantation

Background: Some complications are frequently seen in pregnancies with kidney transplantation and graft functions may be impaired. In this study, it was aimed to examine the course and results of pregnancies after transplantation, the effect of pregnancy on graft functions and the risk factors in co...

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Main Authors: Sefik Gökce, Dilşad Herkiloglu, Murathan Uyar
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Transplantation Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2451959621000123
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spelling doaj-cb87da2cb77d40bf90c77e0e92d887462021-09-25T05:09:23ZengElsevierTransplantation Reports2451-95962021-12-0164100084Pregnancy outcomes after kidney transplantationSefik Gökce0Dilşad Herkiloglu1Murathan Uyar2Yeni Yuzyil University, School of Medicine, Private Gaziosmanpasa Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey; Corresponding authors.Yeni Yuzyil University, School of Medicine, Private Gaziosmanpasa Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey; Corresponding authors.Yeni Yuzyil University, School of Medicine, Private Gaziosmanpasa Hospital, Department of Nephrology and Organ Transplantation, Istanbul, TurkeyBackground: Some complications are frequently seen in pregnancies with kidney transplantation and graft functions may be impaired. In this study, it was aimed to examine the course and results of pregnancies after transplantation, the effect of pregnancy on graft functions and the risk factors in complications in these pregnancies. Methods: A total of 24 pregnancies conceived after kidney transplantation due to end-stage renal disease between January 2013 and December 2020 and followed up in the Obstetrics and Gynecology clinic of our hospital were included in the study. Results: The mean age was 31.8±6.4, the mean time between transplantation and pregnancy was 54±36 months, and the mean newborn weight was 1945±529.5 grams.Of the pregnancies, abortion occurred in one (4.2%), preterm delivery in 17 (70.3%), and intrauterine growth retardation (IUGR) in 10 (41.7%). Immunosuppressant treatment was given to all pregnant women due to transplantation, and all women used tacrolimus. No graft rejection was seen.The median serum creatinine level did not show a significant change during pregnancy according to the prenatal value (p>0.05 for each), and it increased significantly in the 6th month (p=0.006) and 3rd year (p=0.007) measurements. Urine protein level increased significantly in the third trimester compared to pre-pregnancy (p=0.009). Conclusion: The findings show that pregnancy does not have a significant effect on maternal and fetal survival, graft rejection and graft function in pregnancies with kidney transplantation, but that complication rates such as hypertension, preterm delivery and low birth weight are high.http://www.sciencedirect.com/science/article/pii/S2451959621000123PregnancyKidney transplantationComplicationGraftTacrolimus
collection DOAJ
language English
format Article
sources DOAJ
author Sefik Gökce
Dilşad Herkiloglu
Murathan Uyar
spellingShingle Sefik Gökce
Dilşad Herkiloglu
Murathan Uyar
Pregnancy outcomes after kidney transplantation
Transplantation Reports
Pregnancy
Kidney transplantation
Complication
Graft
Tacrolimus
author_facet Sefik Gökce
Dilşad Herkiloglu
Murathan Uyar
author_sort Sefik Gökce
title Pregnancy outcomes after kidney transplantation
title_short Pregnancy outcomes after kidney transplantation
title_full Pregnancy outcomes after kidney transplantation
title_fullStr Pregnancy outcomes after kidney transplantation
title_full_unstemmed Pregnancy outcomes after kidney transplantation
title_sort pregnancy outcomes after kidney transplantation
publisher Elsevier
series Transplantation Reports
issn 2451-9596
publishDate 2021-12-01
description Background: Some complications are frequently seen in pregnancies with kidney transplantation and graft functions may be impaired. In this study, it was aimed to examine the course and results of pregnancies after transplantation, the effect of pregnancy on graft functions and the risk factors in complications in these pregnancies. Methods: A total of 24 pregnancies conceived after kidney transplantation due to end-stage renal disease between January 2013 and December 2020 and followed up in the Obstetrics and Gynecology clinic of our hospital were included in the study. Results: The mean age was 31.8±6.4, the mean time between transplantation and pregnancy was 54±36 months, and the mean newborn weight was 1945±529.5 grams.Of the pregnancies, abortion occurred in one (4.2%), preterm delivery in 17 (70.3%), and intrauterine growth retardation (IUGR) in 10 (41.7%). Immunosuppressant treatment was given to all pregnant women due to transplantation, and all women used tacrolimus. No graft rejection was seen.The median serum creatinine level did not show a significant change during pregnancy according to the prenatal value (p>0.05 for each), and it increased significantly in the 6th month (p=0.006) and 3rd year (p=0.007) measurements. Urine protein level increased significantly in the third trimester compared to pre-pregnancy (p=0.009). Conclusion: The findings show that pregnancy does not have a significant effect on maternal and fetal survival, graft rejection and graft function in pregnancies with kidney transplantation, but that complication rates such as hypertension, preterm delivery and low birth weight are high.
topic Pregnancy
Kidney transplantation
Complication
Graft
Tacrolimus
url http://www.sciencedirect.com/science/article/pii/S2451959621000123
work_keys_str_mv AT sefikgokce pregnancyoutcomesafterkidneytransplantation
AT dilsadherkiloglu pregnancyoutcomesafterkidneytransplantation
AT murathanuyar pregnancyoutcomesafterkidneytransplantation
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