Pregnancy outcomes after kidney transplantation
Background: Some complications are frequently seen in pregnancies with kidney transplantation and graft functions may be impaired. In this study, it was aimed to examine the course and results of pregnancies after transplantation, the effect of pregnancy on graft functions and the risk factors in co...
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2021-12-01
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doaj-cb87da2cb77d40bf90c77e0e92d887462021-09-25T05:09:23ZengElsevierTransplantation Reports2451-95962021-12-0164100084Pregnancy outcomes after kidney transplantationSefik Gökce0Dilşad Herkiloglu1Murathan Uyar2Yeni Yuzyil University, School of Medicine, Private Gaziosmanpasa Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey; Corresponding authors.Yeni Yuzyil University, School of Medicine, Private Gaziosmanpasa Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey; Corresponding authors.Yeni Yuzyil University, School of Medicine, Private Gaziosmanpasa Hospital, Department of Nephrology and Organ Transplantation, Istanbul, TurkeyBackground: Some complications are frequently seen in pregnancies with kidney transplantation and graft functions may be impaired. In this study, it was aimed to examine the course and results of pregnancies after transplantation, the effect of pregnancy on graft functions and the risk factors in complications in these pregnancies. Methods: A total of 24 pregnancies conceived after kidney transplantation due to end-stage renal disease between January 2013 and December 2020 and followed up in the Obstetrics and Gynecology clinic of our hospital were included in the study. Results: The mean age was 31.8±6.4, the mean time between transplantation and pregnancy was 54±36 months, and the mean newborn weight was 1945±529.5 grams.Of the pregnancies, abortion occurred in one (4.2%), preterm delivery in 17 (70.3%), and intrauterine growth retardation (IUGR) in 10 (41.7%). Immunosuppressant treatment was given to all pregnant women due to transplantation, and all women used tacrolimus. No graft rejection was seen.The median serum creatinine level did not show a significant change during pregnancy according to the prenatal value (p>0.05 for each), and it increased significantly in the 6th month (p=0.006) and 3rd year (p=0.007) measurements. Urine protein level increased significantly in the third trimester compared to pre-pregnancy (p=0.009). Conclusion: The findings show that pregnancy does not have a significant effect on maternal and fetal survival, graft rejection and graft function in pregnancies with kidney transplantation, but that complication rates such as hypertension, preterm delivery and low birth weight are high.http://www.sciencedirect.com/science/article/pii/S2451959621000123PregnancyKidney transplantationComplicationGraftTacrolimus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sefik Gökce Dilşad Herkiloglu Murathan Uyar |
spellingShingle |
Sefik Gökce Dilşad Herkiloglu Murathan Uyar Pregnancy outcomes after kidney transplantation Transplantation Reports Pregnancy Kidney transplantation Complication Graft Tacrolimus |
author_facet |
Sefik Gökce Dilşad Herkiloglu Murathan Uyar |
author_sort |
Sefik Gökce |
title |
Pregnancy outcomes after kidney transplantation |
title_short |
Pregnancy outcomes after kidney transplantation |
title_full |
Pregnancy outcomes after kidney transplantation |
title_fullStr |
Pregnancy outcomes after kidney transplantation |
title_full_unstemmed |
Pregnancy outcomes after kidney transplantation |
title_sort |
pregnancy outcomes after kidney transplantation |
publisher |
Elsevier |
series |
Transplantation Reports |
issn |
2451-9596 |
publishDate |
2021-12-01 |
description |
Background: Some complications are frequently seen in pregnancies with kidney transplantation and graft functions may be impaired. In this study, it was aimed to examine the course and results of pregnancies after transplantation, the effect of pregnancy on graft functions and the risk factors in complications in these pregnancies. Methods: A total of 24 pregnancies conceived after kidney transplantation due to end-stage renal disease between January 2013 and December 2020 and followed up in the Obstetrics and Gynecology clinic of our hospital were included in the study. Results: The mean age was 31.8±6.4, the mean time between transplantation and pregnancy was 54±36 months, and the mean newborn weight was 1945±529.5 grams.Of the pregnancies, abortion occurred in one (4.2%), preterm delivery in 17 (70.3%), and intrauterine growth retardation (IUGR) in 10 (41.7%). Immunosuppressant treatment was given to all pregnant women due to transplantation, and all women used tacrolimus. No graft rejection was seen.The median serum creatinine level did not show a significant change during pregnancy according to the prenatal value (p>0.05 for each), and it increased significantly in the 6th month (p=0.006) and 3rd year (p=0.007) measurements. Urine protein level increased significantly in the third trimester compared to pre-pregnancy (p=0.009). Conclusion: The findings show that pregnancy does not have a significant effect on maternal and fetal survival, graft rejection and graft function in pregnancies with kidney transplantation, but that complication rates such as hypertension, preterm delivery and low birth weight are high. |
topic |
Pregnancy Kidney transplantation Complication Graft Tacrolimus |
url |
http://www.sciencedirect.com/science/article/pii/S2451959621000123 |
work_keys_str_mv |
AT sefikgokce pregnancyoutcomesafterkidneytransplantation AT dilsadherkiloglu pregnancyoutcomesafterkidneytransplantation AT murathanuyar pregnancyoutcomesafterkidneytransplantation |
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