Cortical T2-hyperintense lesions as the initial MRI finding in glioblastoma
Early MRI findings in GBM can include ill-defined T2-hyperinsities throughout grey and white matter, often with enhancement. Outside of animal models and a single prior case series, little has been reported on GBM manifesting within cortex. We report a series of three patients in whom GBM initially...
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2021-03-01
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doaj-cb89d4d43ad448ee9f475f313e9031b62020-12-15T04:10:17ZengElsevierInterdisciplinary Neurosurgery2214-75192021-03-0123100993Cortical T2-hyperintense lesions as the initial MRI finding in glioblastomaTimothy A. Gregory0John W. Henson1Department of Medicine, Neurology, Madigan Army Medical Center, Tacoma, WA, United StatesBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Medical Center, Seattle, WA, United States; Corresponding author at: 550 17th Avenue, Suite 500, Seattle, WA 98122, United States.Early MRI findings in GBM can include ill-defined T2-hyperinsities throughout grey and white matter, often with enhancement. Outside of animal models and a single prior case series, little has been reported on GBM manifesting within cortex. We report a series of three patients in whom GBM initially presented with early cortical findings, indicating that grey matter lesions can be the first detectable radiographic feature in a subset of patients. New-onset seizures may present with similar cortical ribbon changes, creating a diagnostic challenge as illustrated by two of our reported cases who initially presented with seizures and cortical abnormalities. Our series highlights the imperative for short interval imaging follow-up in such patients and indicates the need to consider suspicious cortical lesions when planning the radiation treatment field.http://www.sciencedirect.com/science/article/pii/S2214751920305545GlioblastomaNeuroimagingCortical lesions |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Timothy A. Gregory John W. Henson |
spellingShingle |
Timothy A. Gregory John W. Henson Cortical T2-hyperintense lesions as the initial MRI finding in glioblastoma Interdisciplinary Neurosurgery Glioblastoma Neuroimaging Cortical lesions |
author_facet |
Timothy A. Gregory John W. Henson |
author_sort |
Timothy A. Gregory |
title |
Cortical T2-hyperintense lesions as the initial MRI finding in glioblastoma |
title_short |
Cortical T2-hyperintense lesions as the initial MRI finding in glioblastoma |
title_full |
Cortical T2-hyperintense lesions as the initial MRI finding in glioblastoma |
title_fullStr |
Cortical T2-hyperintense lesions as the initial MRI finding in glioblastoma |
title_full_unstemmed |
Cortical T2-hyperintense lesions as the initial MRI finding in glioblastoma |
title_sort |
cortical t2-hyperintense lesions as the initial mri finding in glioblastoma |
publisher |
Elsevier |
series |
Interdisciplinary Neurosurgery |
issn |
2214-7519 |
publishDate |
2021-03-01 |
description |
Early MRI findings in GBM can include ill-defined T2-hyperinsities throughout grey and white matter, often with enhancement. Outside of animal models and a single prior case series, little has been reported on GBM manifesting within cortex. We report a series of three patients in whom GBM initially presented with early cortical findings, indicating that grey matter lesions can be the first detectable radiographic feature in a subset of patients. New-onset seizures may present with similar cortical ribbon changes, creating a diagnostic challenge as illustrated by two of our reported cases who initially presented with seizures and cortical abnormalities. Our series highlights the imperative for short interval imaging follow-up in such patients and indicates the need to consider suspicious cortical lesions when planning the radiation treatment field. |
topic |
Glioblastoma Neuroimaging Cortical lesions |
url |
http://www.sciencedirect.com/science/article/pii/S2214751920305545 |
work_keys_str_mv |
AT timothyagregory corticalt2hyperintenselesionsastheinitialmrifindinginglioblastoma AT johnwhenson corticalt2hyperintenselesionsastheinitialmrifindinginglioblastoma |
_version_ |
1724382845699358720 |