Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity

Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity

Ecto-nucleotidase triphosphate diphosphohydrolase-2 (NTPDase2) is an ecto-enzyme that is expressed on portal fibroblasts in the liver that modulates P2 receptor signaling by regulating local concentrations of extracellular ATP and ADP. NTPDase2 has protective properties in liver fibrosis and may imp...

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Bibliographic Details
Main Authors: Linda Feldbrügge, Katrin Splith, Ines Kämmerer, Sandra Richter, Anna Riddermann, Santiago Andres Ortiz Galindo, Felix Krenzien, Tobias Müller, Eva Csizmadia, Johann Pratschke, Simon C. Robson, Moritz Schmelzle
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
Entpd2
NTPDase2
purinergic signaling
APAP hepatotoxicity
Online Access:https://www.mdpi.com/1422-0067/21/17/5998

Internet

https://www.mdpi.com/1422-0067/21/17/5998

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