Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective Study
Acute kidney injury (AKI) is one of the most frequent postoperative complications after liver transplantation (LT). Increased serum ammonia levels due to the liver disease itself may affect postoperative renal function. This study aimed to compare the incidence of postoperative AKI according to preo...
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doaj-cba2ba0dc1da43da87f6a790e15dbb272020-11-25T03:33:49ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0191629162910.3390/jcm9061629Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective StudyYoon Sook Lee0Yoon Ji Choi1Kyu Hee Park2Byeong Seon Park3Jung-Min Son4Ju Yeon Park5Hyun-Su Ri6Je Ho Ryu7Department of Anaesthesiology and Pain Medicine, Ansan Hospital, Korea University, College of Medicine, Ansan 15355, KoreaDepartment of Anaesthesiology and Pain Medicine, Ansan Hospital, Korea University, College of Medicine, Ansan 15355, KoreaDepartment of Pediatrics, Korea University Hospital, Ansan 15355, KoreaDepartment of Anaesthesiology and Pain Medicine, Ansan Hospital, Korea University, College of Medicine, Ansan 15355, KoreaDepartment of Biostatistics, Clinical Trial Center, Biomedical Research Institute, Pusan National University Hospital, Pusan 49241, KoreaDepartment of Anesthesiology and Pain Medicine, Daedong Hospital, Busan 47737, KoreaDepartment of Anaesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, KoreaDivision of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan 50612, KoreaAcute kidney injury (AKI) is one of the most frequent postoperative complications after liver transplantation (LT). Increased serum ammonia levels due to the liver disease itself may affect postoperative renal function. This study aimed to compare the incidence of postoperative AKI according to preoperative serum ammonia levels in patients after LT. Medical records from 436 patients who underwent LT from January 2010 to February 2020 in a single university hospital were retrospectively reviewed. The patients were then categorized according to changes in plasma creatinine concentrations within 48 h of LT using the Acute Kidney Injury Network criteria. A preoperative serum ammonia level above 45 mg/dL was associated with postoperative AKI (<i>p</i> < 0.0001). Even in patients with a normal preoperative creatinine level, when the ammonia level was greater than 45 μg/dL, the incidence of postoperative AKI was significantly higher (<i>p</i> < 0.0001); the AKI stage was also higher in this group than in the group with preoperative ammonia levels less than or equal to 45 μg/dL (<i>p</i> < 0.0001). Based on the results of our research, an elevation in preoperative serum ammonia levels above 45 μg/dL is related to postoperative AKI after LT.https://www.mdpi.com/2077-0383/9/6/1629acute kidney injuryammoniacomplicationliver transplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoon Sook Lee Yoon Ji Choi Kyu Hee Park Byeong Seon Park Jung-Min Son Ju Yeon Park Hyun-Su Ri Je Ho Ryu |
spellingShingle |
Yoon Sook Lee Yoon Ji Choi Kyu Hee Park Byeong Seon Park Jung-Min Son Ju Yeon Park Hyun-Su Ri Je Ho Ryu Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective Study Journal of Clinical Medicine acute kidney injury ammonia complication liver transplantation |
author_facet |
Yoon Sook Lee Yoon Ji Choi Kyu Hee Park Byeong Seon Park Jung-Min Son Ju Yeon Park Hyun-Su Ri Je Ho Ryu |
author_sort |
Yoon Sook Lee |
title |
Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective Study |
title_short |
Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective Study |
title_full |
Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective Study |
title_fullStr |
Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective Study |
title_full_unstemmed |
Liver Transplant Patients with High Levels of Preoperative Serum Ammonia Are at Increased Risk for Postoperative Acute Kidney Injury: A Retrospective Study |
title_sort |
liver transplant patients with high levels of preoperative serum ammonia are at increased risk for postoperative acute kidney injury: a retrospective study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-05-01 |
description |
Acute kidney injury (AKI) is one of the most frequent postoperative complications after liver transplantation (LT). Increased serum ammonia levels due to the liver disease itself may affect postoperative renal function. This study aimed to compare the incidence of postoperative AKI according to preoperative serum ammonia levels in patients after LT. Medical records from 436 patients who underwent LT from January 2010 to February 2020 in a single university hospital were retrospectively reviewed. The patients were then categorized according to changes in plasma creatinine concentrations within 48 h of LT using the Acute Kidney Injury Network criteria. A preoperative serum ammonia level above 45 mg/dL was associated with postoperative AKI (<i>p</i> < 0.0001). Even in patients with a normal preoperative creatinine level, when the ammonia level was greater than 45 μg/dL, the incidence of postoperative AKI was significantly higher (<i>p</i> < 0.0001); the AKI stage was also higher in this group than in the group with preoperative ammonia levels less than or equal to 45 μg/dL (<i>p</i> < 0.0001). Based on the results of our research, an elevation in preoperative serum ammonia levels above 45 μg/dL is related to postoperative AKI after LT. |
topic |
acute kidney injury ammonia complication liver transplantation |
url |
https://www.mdpi.com/2077-0383/9/6/1629 |
work_keys_str_mv |
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