TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background

TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background

The p53 gene family network plays a pivotal role in the control of many biological processes and therefore the right balance between the pro-apoptotic and pro-survival isoforms is key to maintain cellular homeostasis. The stability of the p53 tumor suppressor protein and that of oncogenic ΔNp63α, is...

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Bibliographic Details
Main Authors: Mariano Francesco Caratozzolo, Flaviana Marzano, Daniela Isabel Abbrescia, Francesca Mastropasqua, Vittoria Petruzzella, Viola Calabrò, Graziano Pesole, Elisabetta Sbisà, Luisa Guerrini, Apollonia Tullo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
TRIM8
p53
ΔNp63α
chemoresistant tumors
caspase-1
proteasome
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01154/full

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