Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma
<b> </b>Surgical resection is considered a standard therapy for malignant melanoma (MM). However, it has not yet been established as an optimal treatment strategy for gynecological MMs, particularly owing to their very low incidence rates. We retrospectively analyzed clinical outcomes of...
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doaj-cbb550f4aa88411ea9518f726df0ce282020-11-24T21:44:27ZengMDPI AGCancers2072-66942019-04-0111448210.3390/cancers11040482cancers11040482Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological MelanomaHiroto Murata0Noriyuki Okonogi1Masaru Wakatsuki2Shingo Kato3Hiroki Kiyohara4Kumiko Karasawa5Tatsuya Ohno6Takashi Nakano7Tadashi Kamada8Makio Shozu9The Working Group of Gynecological TumorsQST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, JapanQST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, JapanDepartment of Radiology, Jichi Medical University, Tochigi 329-0498, JapanDepartment of Radiation Oncology, Saitama Medical University International Medical Center, Saitama 350-1298, JapanDepartment of Radiation Oncology, Japanese Red Cross Maebashi Hospital, Maebashi 371-0811, JapanDepartment of Radiation Oncology, Tokyo Women’s Medical University School of Medicine, Tokyo 162-8666, JapanDepartment of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi 371-8511, JapanDepartment of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi 371-8511, JapanQST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, JapanDepartment of Reproductive Medicine, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan<b> </b>Surgical resection is considered a standard therapy for malignant melanoma (MM). However, it has not yet been established as an optimal treatment strategy for gynecological MMs, particularly owing to their very low incidence rates. We retrospectively analyzed clinical outcomes of carbon-ion radiotherapy (C-ion RT) for gynecological MMs. The eligibility criterion was the presence of histologically confirmed gynecological MM. Patients with pelvic or inguinal lymph node metastases were included, while those with distant metastases were excluded. The pelvic and inguinal lymph node regions were irradiated with up to 36 gray relative biological effectiveness (Gy (RBE)) followed by a gross tumor volume boost of up to 57.6 Gy (RBE) or 64 Gy (RBE) in 16 fractions over 4 weeks. Thirty-seven patients (median age: 71 years) were examined. In total, 22 patients had vaginal tumors, 12 had vulval tumors, and 3 had cervical uterine tumors. The median follow-up periods were 23 months (range: 5–103 months) for all patients and 53 months (range: 16–103 months) for survivors. Thirty of 37 patients (81%) achieved complete tumor disappearance. The 2-year local control, overall survival, and progression-free survival rates were 71%, 53%, and 29%, respectively. C-ion RT may be a definitive treatment option for patients with gynecological MM.https://www.mdpi.com/2072-6694/11/4/482carbon-ion radiotherapygynecologymelanomalong-term outcomesparticle beam therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroto Murata Noriyuki Okonogi Masaru Wakatsuki Shingo Kato Hiroki Kiyohara Kumiko Karasawa Tatsuya Ohno Takashi Nakano Tadashi Kamada Makio Shozu The Working Group of Gynecological Tumors |
spellingShingle |
Hiroto Murata Noriyuki Okonogi Masaru Wakatsuki Shingo Kato Hiroki Kiyohara Kumiko Karasawa Tatsuya Ohno Takashi Nakano Tadashi Kamada Makio Shozu The Working Group of Gynecological Tumors Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma Cancers carbon-ion radiotherapy gynecology melanoma long-term outcomes particle beam therapy |
author_facet |
Hiroto Murata Noriyuki Okonogi Masaru Wakatsuki Shingo Kato Hiroki Kiyohara Kumiko Karasawa Tatsuya Ohno Takashi Nakano Tadashi Kamada Makio Shozu The Working Group of Gynecological Tumors |
author_sort |
Hiroto Murata |
title |
Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma |
title_short |
Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma |
title_full |
Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma |
title_fullStr |
Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma |
title_full_unstemmed |
Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma |
title_sort |
long-term outcomes of carbon-ion radiotherapy for malignant gynecological melanoma |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-04-01 |
description |
<b> </b>Surgical resection is considered a standard therapy for malignant melanoma (MM). However, it has not yet been established as an optimal treatment strategy for gynecological MMs, particularly owing to their very low incidence rates. We retrospectively analyzed clinical outcomes of carbon-ion radiotherapy (C-ion RT) for gynecological MMs. The eligibility criterion was the presence of histologically confirmed gynecological MM. Patients with pelvic or inguinal lymph node metastases were included, while those with distant metastases were excluded. The pelvic and inguinal lymph node regions were irradiated with up to 36 gray relative biological effectiveness (Gy (RBE)) followed by a gross tumor volume boost of up to 57.6 Gy (RBE) or 64 Gy (RBE) in 16 fractions over 4 weeks. Thirty-seven patients (median age: 71 years) were examined. In total, 22 patients had vaginal tumors, 12 had vulval tumors, and 3 had cervical uterine tumors. The median follow-up periods were 23 months (range: 5–103 months) for all patients and 53 months (range: 16–103 months) for survivors. Thirty of 37 patients (81%) achieved complete tumor disappearance. The 2-year local control, overall survival, and progression-free survival rates were 71%, 53%, and 29%, respectively. C-ion RT may be a definitive treatment option for patients with gynecological MM. |
topic |
carbon-ion radiotherapy gynecology melanoma long-term outcomes particle beam therapy |
url |
https://www.mdpi.com/2072-6694/11/4/482 |
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