Discovery of Furanoquinone Derivatives as a Novel Class of DNA Polymerase and Gyrase Inhibitors for MRSA Eradication in Cutaneous Infection

Discovery of Furanoquinone Derivatives as a Novel Class of DNA Polymerase and Gyrase Inhibitors for MRSA Eradication in Cutaneous Infection

Methicillin-resistant Staphylococcus aureus (MRSA) is the primary microbe responsible for skin infections that are particularly difficult to eradicate. This study sought to inhibit planktonic and biofilm MRSA using furanoquinone-derived compounds containing imine moiety. A total of 19 furanoquinone...

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Bibliographic Details
Main Authors: Shih-Chun Yang, Kai-Wei Tang, Chih-Hung Lin, Ahmed Alalaiwe, Chih-Hua Tseng, Jia-You Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Microbiology
Subjects:
MRSA
furanoquinone
skin
DNA polymerase
gyrase
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01197/full

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