Primary Sjogren’s syndrome: clinical and serological feature of a single centre
Objective: To describe clinical and serological features of a large series of patients affected by primary Sjogren’s syndrome (pSS), assessing the evolution of the disease in a long-term follow-up study. Methods: Clinical and laboratory data of 250 patients with pSS attending our Unit for a mean fol...
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2011-09-01
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Series: | Reumatismo |
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doaj-cbb9da7165134888b075761cdefee6552020-11-24T23:22:00ZengPAGEPress PublicationsReumatismo0048-74492240-26832011-09-0157425626110.4081/reumatismo.2005.256Primary Sjogren’s syndrome: clinical and serological feature of a single centreM. SebastianiG. MerliniA. TavoniC. BaldiniS. BombardieriObjective: To describe clinical and serological features of a large series of patients affected by primary Sjogren’s syndrome (pSS), assessing the evolution of the disease in a long-term follow-up study. Methods: Clinical and laboratory data of 250 patients with pSS attending our Unit for a mean follow-up period of 140 months were retrospectively collected and analysed. In all the cases the diagnosis was made according with the recent international criteria. Results: Glandular involvement was almost universally present, typically as the first manifestation of the disease and a slow progression of the salivary and lachrymal dysfunction was seen during the observation period. Extraglandular involvement was mild, quite rare and delayed. The respective percentages for muscle-skeletal disease, urogenital, haematological, skin, pulmonary, gastrointestinal, neurological and renal involvement were 60%, 40%, 24%, 20%, 11%, 7%, 8% and 3%. Only 6 patients developed a lymphoma. The serological pattern of the majority of patients remained constant throughout the follow-up period. Conclusions: pSS is often a benign condition. Since some patients may develop lymphoid malignancies, clinical follow- up is recommended.http://www.reumatismo.org/index.php/reuma/article/view/226 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Sebastiani G. Merlini A. Tavoni C. Baldini S. Bombardieri |
spellingShingle |
M. Sebastiani G. Merlini A. Tavoni C. Baldini S. Bombardieri Primary Sjogren’s syndrome: clinical and serological feature of a single centre Reumatismo |
author_facet |
M. Sebastiani G. Merlini A. Tavoni C. Baldini S. Bombardieri |
author_sort |
M. Sebastiani |
title |
Primary Sjogren’s syndrome: clinical and serological feature of a single centre |
title_short |
Primary Sjogren’s syndrome: clinical and serological feature of a single centre |
title_full |
Primary Sjogren’s syndrome: clinical and serological feature of a single centre |
title_fullStr |
Primary Sjogren’s syndrome: clinical and serological feature of a single centre |
title_full_unstemmed |
Primary Sjogren’s syndrome: clinical and serological feature of a single centre |
title_sort |
primary sjogren’s syndrome: clinical and serological feature of a single centre |
publisher |
PAGEPress Publications |
series |
Reumatismo |
issn |
0048-7449 2240-2683 |
publishDate |
2011-09-01 |
description |
Objective: To describe clinical and serological features of a large series of patients affected by primary Sjogren’s syndrome (pSS), assessing the evolution of the disease in a long-term follow-up study. Methods: Clinical and laboratory data of 250 patients with pSS attending our Unit for a mean follow-up period of 140 months were retrospectively collected and analysed. In all the cases the diagnosis was made according with the recent international criteria. Results: Glandular involvement was almost universally present, typically as the first manifestation of the disease and a slow progression of the salivary and lachrymal dysfunction was seen during the observation period. Extraglandular involvement was mild, quite rare and delayed. The respective percentages for muscle-skeletal disease, urogenital, haematological, skin, pulmonary, gastrointestinal, neurological and renal involvement were 60%, 40%, 24%, 20%, 11%, 7%, 8% and 3%. Only 6 patients developed a lymphoma. The serological pattern of the majority of patients remained constant throughout the follow-up period. Conclusions: pSS is often a benign condition. Since some patients may develop lymphoid malignancies, clinical follow- up is recommended. |
url |
http://www.reumatismo.org/index.php/reuma/article/view/226 |
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