Primary Sjogren’s syndrome: clinical and serological feature of a single centre

Objective: To describe clinical and serological features of a large series of patients affected by primary Sjogren’s syndrome (pSS), assessing the evolution of the disease in a long-term follow-up study. Methods: Clinical and laboratory data of 250 patients with pSS attending our Unit for a mean fol...

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Main Authors: M. Sebastiani, G. Merlini, A. Tavoni, C. Baldini, S. Bombardieri
Format: Article
Language:English
Published: PAGEPress Publications 2011-09-01
Series:Reumatismo
Online Access:http://www.reumatismo.org/index.php/reuma/article/view/226
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spelling doaj-cbb9da7165134888b075761cdefee6552020-11-24T23:22:00ZengPAGEPress PublicationsReumatismo0048-74492240-26832011-09-0157425626110.4081/reumatismo.2005.256Primary Sjogren’s syndrome: clinical and serological feature of a single centreM. SebastianiG. MerliniA. TavoniC. BaldiniS. BombardieriObjective: To describe clinical and serological features of a large series of patients affected by primary Sjogren’s syndrome (pSS), assessing the evolution of the disease in a long-term follow-up study. Methods: Clinical and laboratory data of 250 patients with pSS attending our Unit for a mean follow-up period of 140 months were retrospectively collected and analysed. In all the cases the diagnosis was made according with the recent international criteria. Results: Glandular involvement was almost universally present, typically as the first manifestation of the disease and a slow progression of the salivary and lachrymal dysfunction was seen during the observation period. Extraglandular involvement was mild, quite rare and delayed. The respective percentages for muscle-skeletal disease, urogenital, haematological, skin, pulmonary, gastrointestinal, neurological and renal involvement were 60%, 40%, 24%, 20%, 11%, 7%, 8% and 3%. Only 6 patients developed a lymphoma. The serological pattern of the majority of patients remained constant throughout the follow-up period. Conclusions: pSS is often a benign condition. Since some patients may develop lymphoid malignancies, clinical follow- up is recommended.http://www.reumatismo.org/index.php/reuma/article/view/226
collection DOAJ
language English
format Article
sources DOAJ
author M. Sebastiani
G. Merlini
A. Tavoni
C. Baldini
S. Bombardieri
spellingShingle M. Sebastiani
G. Merlini
A. Tavoni
C. Baldini
S. Bombardieri
Primary Sjogren’s syndrome: clinical and serological feature of a single centre
Reumatismo
author_facet M. Sebastiani
G. Merlini
A. Tavoni
C. Baldini
S. Bombardieri
author_sort M. Sebastiani
title Primary Sjogren’s syndrome: clinical and serological feature of a single centre
title_short Primary Sjogren’s syndrome: clinical and serological feature of a single centre
title_full Primary Sjogren’s syndrome: clinical and serological feature of a single centre
title_fullStr Primary Sjogren’s syndrome: clinical and serological feature of a single centre
title_full_unstemmed Primary Sjogren’s syndrome: clinical and serological feature of a single centre
title_sort primary sjogren’s syndrome: clinical and serological feature of a single centre
publisher PAGEPress Publications
series Reumatismo
issn 0048-7449
2240-2683
publishDate 2011-09-01
description Objective: To describe clinical and serological features of a large series of patients affected by primary Sjogren’s syndrome (pSS), assessing the evolution of the disease in a long-term follow-up study. Methods: Clinical and laboratory data of 250 patients with pSS attending our Unit for a mean follow-up period of 140 months were retrospectively collected and analysed. In all the cases the diagnosis was made according with the recent international criteria. Results: Glandular involvement was almost universally present, typically as the first manifestation of the disease and a slow progression of the salivary and lachrymal dysfunction was seen during the observation period. Extraglandular involvement was mild, quite rare and delayed. The respective percentages for muscle-skeletal disease, urogenital, haematological, skin, pulmonary, gastrointestinal, neurological and renal involvement were 60%, 40%, 24%, 20%, 11%, 7%, 8% and 3%. Only 6 patients developed a lymphoma. The serological pattern of the majority of patients remained constant throughout the follow-up period. Conclusions: pSS is often a benign condition. Since some patients may develop lymphoid malignancies, clinical follow- up is recommended.
url http://www.reumatismo.org/index.php/reuma/article/view/226
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