Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy

Bloch–Siegert shifts prevent the accurate observation of resonance frequencies in NMR experiments. Here the authors present a method for homonuclear decoupling that avoids inducing Bloch–Siegert shifts and improves the sensitivity and resolution of HNCA experiments.

Bibliographic Details
Main Authors:	Paul W. Coote, Scott A. Robson, Abhinav Dubey, Andras Boeszoermenyi, Mengxia Zhao, Gerhard Wagner, Haribabu Arthanari
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05400-4

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spelling	doaj-cbceedd19fe04e49a3cca526a7eddfc52021-05-11T09:27:35ZengNature Publishing GroupNature Communications2041-17232018-08-01911910.1038/s41467-018-05400-4Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopyPaul W. Coote0Scott A. Robson1Abhinav Dubey2Andras Boeszoermenyi3Mengxia Zhao4Gerhard Wagner5Haribabu Arthanari6Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolDana-Farber Cancer InstituteDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolDepartment of Chemistry and Chemical Biology, Harvard UniversityDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolBloch–Siegert shifts prevent the accurate observation of resonance frequencies in NMR experiments. Here the authors present a method for homonuclear decoupling that avoids inducing Bloch–Siegert shifts and improves the sensitivity and resolution of HNCA experiments.https://doi.org/10.1038/s41467-018-05400-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Paul W. Coote Scott A. Robson Abhinav Dubey Andras Boeszoermenyi Mengxia Zhao Gerhard Wagner Haribabu Arthanari
spellingShingle	Paul W. Coote Scott A. Robson Abhinav Dubey Andras Boeszoermenyi Mengxia Zhao Gerhard Wagner Haribabu Arthanari Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy Nature Communications
author_facet	Paul W. Coote Scott A. Robson Abhinav Dubey Andras Boeszoermenyi Mengxia Zhao Gerhard Wagner Haribabu Arthanari
author_sort	Paul W. Coote
title	Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy
title_short	Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy
title_full	Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy
title_fullStr	Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy
title_full_unstemmed	Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy
title_sort	optimal control theory enables homonuclear decoupling without bloch–siegert shifts in nmr spectroscopy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-08-01
description	Bloch–Siegert shifts prevent the accurate observation of resonance frequencies in NMR experiments. Here the authors present a method for homonuclear decoupling that avoids inducing Bloch–Siegert shifts and improves the sensitivity and resolution of HNCA experiments.
url	https://doi.org/10.1038/s41467-018-05400-4
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Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy

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