Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research

To gain regulatory approval for the clinical use of knee biologics and devices in humans, translational large-animal studies are typically required. Animal models that permit second-look arthroscopy are valuable because they allow for longitudinal assessment of the treated tissue without needing to...

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Main Authors:	Dean Wang, M.D., Mark Cubberly, M.D., Wendy E. Brown, Ph.D., Heenam Kwon, Ph.D., Jerry C. Hu, Ph.D., Kyriacos A. Athanasiou, Ph.D.
Format:	Article
Language:	English
Published:	Elsevier 2021-02-01
Series:	Arthroscopy Techniques
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212628720302863

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spelling	doaj-cbd5a361cc42490a8d3a45bb5661b5062021-06-11T05:13:54ZengElsevierArthroscopy Techniques2212-62872021-02-01102e297e301Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal ResearchDean Wang, M.D.0Mark Cubberly, M.D.1Wendy E. Brown, Ph.D.2Heenam Kwon, Ph.D.3Jerry C. Hu, Ph.D.4Kyriacos A. Athanasiou, Ph.D.5Department of Orthopaedic Surgery, University of California Irvine, Irvine, California, U.S.A.; Address correspondence to Dean Wang, M.D., Department of Orthopaedic Surgery, UCI Health, 101 The City Dr S, Pav III, Orange, CA 92868, U.S.A.Department of Orthopaedic Surgery, University of California Irvine, Irvine, California, U.S.A.Department of Biomedical Engineering, University of California Irvine, Irvine, California, U.S.A.Department of Biomedical Engineering, University of California Irvine, Irvine, California, U.S.A.Department of Biomedical Engineering, University of California Irvine, Irvine, California, U.S.A.Department of Biomedical Engineering, University of California Irvine, Irvine, California, U.S.A.To gain regulatory approval for the clinical use of knee biologics and devices in humans, translational large-animal studies are typically required. Animal models that permit second-look arthroscopy are valuable because they allow for longitudinal assessment of the treated tissue without needing to sacrifice the animal. The minipig is an ideal preclinical animal model for the investigation of therapies for the knee, in part because arthroscopy can be performed in its stifle (knee) joint with the use of standard surgical equipment used in humans. The purpose of this Technical Note is to describe a reproducible technique for diagnostic arthroscopy of the minipig stifle (knee) joint.http://www.sciencedirect.com/science/article/pii/S2212628720302863
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dean Wang, M.D. Mark Cubberly, M.D. Wendy E. Brown, Ph.D. Heenam Kwon, Ph.D. Jerry C. Hu, Ph.D. Kyriacos A. Athanasiou, Ph.D.
spellingShingle	Dean Wang, M.D. Mark Cubberly, M.D. Wendy E. Brown, Ph.D. Heenam Kwon, Ph.D. Jerry C. Hu, Ph.D. Kyriacos A. Athanasiou, Ph.D. Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research Arthroscopy Techniques
author_facet	Dean Wang, M.D. Mark Cubberly, M.D. Wendy E. Brown, Ph.D. Heenam Kwon, Ph.D. Jerry C. Hu, Ph.D. Kyriacos A. Athanasiou, Ph.D.
author_sort	Dean Wang, M.D.
title	Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research
title_short	Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research
title_full	Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research
title_fullStr	Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research
title_full_unstemmed	Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research
title_sort	diagnostic arthroscopy of the minipig stifle (knee) for translational large animal research
publisher	Elsevier
series	Arthroscopy Techniques
issn	2212-6287
publishDate	2021-02-01
description	To gain regulatory approval for the clinical use of knee biologics and devices in humans, translational large-animal studies are typically required. Animal models that permit second-look arthroscopy are valuable because they allow for longitudinal assessment of the treated tissue without needing to sacrifice the animal. The minipig is an ideal preclinical animal model for the investigation of therapies for the knee, in part because arthroscopy can be performed in its stifle (knee) joint with the use of standard surgical equipment used in humans. The purpose of this Technical Note is to describe a reproducible technique for diagnostic arthroscopy of the minipig stifle (knee) joint.
url	http://www.sciencedirect.com/science/article/pii/S2212628720302863
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Diagnostic Arthroscopy of the Minipig Stifle (Knee) for Translational Large Animal Research

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