Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood–brain barrier, and damage in the nigral dopaminergic system

Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood–brain barrier, and damage in the nigral dopaminergic system

We have evaluated the potential neuroprotectant activity of minocycline in an animal model of Parkinson's disease induced by intranigral injection of lipopolysaccharide. Minocycline treatment was very effective in protecting number of nigral dopaminergic neurons and loss of reactive astrocytes...

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Bibliographic Details
Main Authors:	Mayka Tomás-Camardiel, Inmaculada Rite, Antonio J Herrera, Rocio M de Pablos, Josefina Cano, Alberto Machado, José L Venero
Format:	Article
Language:	English
Published:	Elsevier 2004-06-01
Series:	Neurobiology of Disease
Subjects:	Parkinson's disease Peroxynitrites Microglia Substantia nigra Dopaminergic system
Online Access:	http://www.sciencedirect.com/science/article/pii/S096999610400018X

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