The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1
Dent's disease type 1 is an X-linked tubular disease caused by mutations in the renal chloride channel CLCN-5, and it is characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, and renal failure. Several cases have been described in which the only presenting symptom...
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Sociedade Brasileira de Nefrologia
2012-03-01
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doaj-cbe8fa098b3148738a9ca65d5bc17c142020-11-25T01:18:23ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392012-03-01341788110.1590/S0101-28002012000100013S0101-28002012000100013The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1Maria Helena Vaisbich0Luciana dos Santos Henriques1Takashi Igarashi2Takashi Sekine3George Seki4Vera H Koch5Universidade de São PauloUniversidade de São PauloUniversity of TokyoUniversity of TokyoUniversity of TokyoUniversidade de São PauloDent's disease type 1 is an X-linked tubular disease caused by mutations in the renal chloride channel CLCN-5, and it is characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, and renal failure. Several cases have been described in which the only presenting symptoms were asymptomatic proteinuria, and focal segmental or global glomerulosclerosis. The renal failure in these patients may be caused by hypercalciuria and persistent proteinuria. Therefore, angiotensin converse enzyme inhibitor and thiazides could be useful. Our aim is to report the effects of these drugs in two novel mutations patients with Dent's disease type 1. In this report, no significant correlations between dosage of hydrochlorothiazide and calciuria and no significant correlations between proteinuria and dosage of enalapril were detected. This is important since these are polyuric patients and these drugs could be dangerous to their renal function.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100013&lng=en&tlng=enEnalaprilProteinúriaHipercalciúriaHidroclorotiazidaDoença de Dent |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Helena Vaisbich Luciana dos Santos Henriques Takashi Igarashi Takashi Sekine George Seki Vera H Koch |
spellingShingle |
Maria Helena Vaisbich Luciana dos Santos Henriques Takashi Igarashi Takashi Sekine George Seki Vera H Koch The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1 Brazilian Journal of Nephrology Enalapril Proteinúria Hipercalciúria Hidroclorotiazida Doença de Dent |
author_facet |
Maria Helena Vaisbich Luciana dos Santos Henriques Takashi Igarashi Takashi Sekine George Seki Vera H Koch |
author_sort |
Maria Helena Vaisbich |
title |
The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1 |
title_short |
The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1 |
title_full |
The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1 |
title_fullStr |
The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1 |
title_full_unstemmed |
The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1 |
title_sort |
long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with dent's disease type 1 |
publisher |
Sociedade Brasileira de Nefrologia |
series |
Brazilian Journal of Nephrology |
issn |
2175-8239 |
publishDate |
2012-03-01 |
description |
Dent's disease type 1 is an X-linked tubular disease caused by mutations in the renal chloride channel CLCN-5, and it is characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, and renal failure. Several cases have been described in which the only presenting symptoms were asymptomatic proteinuria, and focal segmental or global glomerulosclerosis. The renal failure in these patients may be caused by hypercalciuria and persistent proteinuria. Therefore, angiotensin converse enzyme inhibitor and thiazides could be useful. Our aim is to report the effects of these drugs in two novel mutations patients with Dent's disease type 1. In this report, no significant correlations between dosage of hydrochlorothiazide and calciuria and no significant correlations between proteinuria and dosage of enalapril were detected. This is important since these are polyuric patients and these drugs could be dangerous to their renal function. |
topic |
Enalapril Proteinúria Hipercalciúria Hidroclorotiazida Doença de Dent |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100013&lng=en&tlng=en |
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