Molecular mechanisms of cold pain
The sensation of cooling is essential for survival. Extreme cold is a noxious stimulus that drives protective behaviour and that we thus perceive as pain. However, chronic pain patients suffering from cold allodynia paradoxically experience innocuous cooling as excruciating pain. Peripheral sensory...
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2020-01-01
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doaj-cbead21232dc4f30a9e3ae6f74601baa2020-11-25T03:26:26ZengElsevierNeurobiology of Pain2452-073X2020-01-017Molecular mechanisms of cold painDonald Iain MacDonald0John N. Wood1Edward C. Emery2Corresponding author.; Wolfson Institute of Biomedical Research, UCL, United KingdomWolfson Institute of Biomedical Research, UCL, United KingdomWolfson Institute of Biomedical Research, UCL, United KingdomThe sensation of cooling is essential for survival. Extreme cold is a noxious stimulus that drives protective behaviour and that we thus perceive as pain. However, chronic pain patients suffering from cold allodynia paradoxically experience innocuous cooling as excruciating pain. Peripheral sensory neurons that detect decreasing temperature express numerous cold-sensitive and voltage-gated ion channels that govern their response to cooling in health and disease. In this review, we discuss how these ion channels control the sense of cooling and cold pain under physiological conditions, before focusing on the molecular mechanisms by which ion channels can trigger pathological cold pain. With the ever-rising number of patients burdened by chronic pain, we end by highlighting the pressing need to define the cells and molecules involved in cold allodynia and so identify new, rational drug targets for the analgesic treatment of cold pain.http://www.sciencedirect.com/science/article/pii/S2452073X20300027PainIon channelsThermosensationNociceptionColdCold allodynia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Donald Iain MacDonald John N. Wood Edward C. Emery |
spellingShingle |
Donald Iain MacDonald John N. Wood Edward C. Emery Molecular mechanisms of cold pain Neurobiology of Pain Pain Ion channels Thermosensation Nociception Cold Cold allodynia |
author_facet |
Donald Iain MacDonald John N. Wood Edward C. Emery |
author_sort |
Donald Iain MacDonald |
title |
Molecular mechanisms of cold pain |
title_short |
Molecular mechanisms of cold pain |
title_full |
Molecular mechanisms of cold pain |
title_fullStr |
Molecular mechanisms of cold pain |
title_full_unstemmed |
Molecular mechanisms of cold pain |
title_sort |
molecular mechanisms of cold pain |
publisher |
Elsevier |
series |
Neurobiology of Pain |
issn |
2452-073X |
publishDate |
2020-01-01 |
description |
The sensation of cooling is essential for survival. Extreme cold is a noxious stimulus that drives protective behaviour and that we thus perceive as pain. However, chronic pain patients suffering from cold allodynia paradoxically experience innocuous cooling as excruciating pain. Peripheral sensory neurons that detect decreasing temperature express numerous cold-sensitive and voltage-gated ion channels that govern their response to cooling in health and disease. In this review, we discuss how these ion channels control the sense of cooling and cold pain under physiological conditions, before focusing on the molecular mechanisms by which ion channels can trigger pathological cold pain. With the ever-rising number of patients burdened by chronic pain, we end by highlighting the pressing need to define the cells and molecules involved in cold allodynia and so identify new, rational drug targets for the analgesic treatment of cold pain. |
topic |
Pain Ion channels Thermosensation Nociception Cold Cold allodynia |
url |
http://www.sciencedirect.com/science/article/pii/S2452073X20300027 |
work_keys_str_mv |
AT donaldiainmacdonald molecularmechanismsofcoldpain AT johnnwood molecularmechanismsofcoldpain AT edwardcemery molecularmechanismsofcoldpain |
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1724592847879929856 |