Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases

Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases

In the cell cycle, there are two checkpoint arrests that allow cells to repair damaged DNA in order to maintain genomic integrity. Many cancer cells have defective G1 checkpoint mechanisms, thus depending on the G2 checkpoint far more than normal cells. G2 checkpoint abrogation is therefore a promis...

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Bibliographic Details
Main Authors: Matthias Schmidt, Alexander Rohe, Charlott Platzer, Abdulkarim Najjar, Frank Erdmann, Wolfgang Sippl
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
G2/M transition
WEE1
PKMYT1
Online Access:https://www.mdpi.com/1420-3049/22/12/2045

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