Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol
Abstract Background Uterine receptivity is one of the determinants of embryo implantation, which is responsible for pregnancy success. Aberrant embryo implantation due to disrupted uterine receptivity is usually found in ovarian hyperstimulation induced hyperoestrogen patients. Results This study id...
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doaj-cc07e2bf71cb457f9f9a973371cc24432021-02-07T12:25:14ZengBMCBMC Developmental Biology1471-213X2020-02-012011810.1186/s12861-020-0208-6Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiolHe Zhang0Huashan Zhao1Xi Wang2Xiaolin Cui3Lingling Jin4College of Basic Medical Sciences, Dalian Medical UniversityCenter for Reproduction and Health Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesCollege of Basic Medical Sciences, Dalian Medical UniversityCollege of Basic Medical Sciences, Dalian Medical UniversityCollege of Basic Medical Sciences, Dalian Medical UniversityAbstract Background Uterine receptivity is one of the determinants of embryo implantation, which is responsible for pregnancy success. Aberrant embryo implantation due to disrupted uterine receptivity is usually found in ovarian hyperstimulation induced hyperoestrogen patients. Results This study identified keratin 86 (KRT86), a fibrous structural protein, which was upregulated in uterine endometrium during peri-implantation. Using a hyperoestrogen mouse model established in a previous study, we found abnormal oestradiol (E2) levels during pre-implantation could trigger high expression of Krt86 in the uterine epithelium. In an ovariectomised mouse model, combining oestrogen receptors ERα and ERβ knockout mice models, uterine Krt86 was found to be up-regulated after E2 treatment, mediated by nuclear ERα. Furthermore, we found progesterone (P4) could ameliorate Krt86 expression, induced by abnormal E2. Conclusions These results revealed the dynamic expression and regulation of Krt86, especially in hyperoestrogen treated mice, indicating it might act as a marker for non-receptive uterus.https://doi.org/10.1186/s12861-020-0208-6ImplantationUterusOestrogenProgesteroneKeratin 86 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
He Zhang Huashan Zhao Xi Wang Xiaolin Cui Lingling Jin |
spellingShingle |
He Zhang Huashan Zhao Xi Wang Xiaolin Cui Lingling Jin Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol BMC Developmental Biology Implantation Uterus Oestrogen Progesterone Keratin 86 |
author_facet |
He Zhang Huashan Zhao Xi Wang Xiaolin Cui Lingling Jin |
author_sort |
He Zhang |
title |
Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_short |
Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_full |
Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_fullStr |
Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_full_unstemmed |
Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_sort |
keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
publisher |
BMC |
series |
BMC Developmental Biology |
issn |
1471-213X |
publishDate |
2020-02-01 |
description |
Abstract Background Uterine receptivity is one of the determinants of embryo implantation, which is responsible for pregnancy success. Aberrant embryo implantation due to disrupted uterine receptivity is usually found in ovarian hyperstimulation induced hyperoestrogen patients. Results This study identified keratin 86 (KRT86), a fibrous structural protein, which was upregulated in uterine endometrium during peri-implantation. Using a hyperoestrogen mouse model established in a previous study, we found abnormal oestradiol (E2) levels during pre-implantation could trigger high expression of Krt86 in the uterine epithelium. In an ovariectomised mouse model, combining oestrogen receptors ERα and ERβ knockout mice models, uterine Krt86 was found to be up-regulated after E2 treatment, mediated by nuclear ERα. Furthermore, we found progesterone (P4) could ameliorate Krt86 expression, induced by abnormal E2. Conclusions These results revealed the dynamic expression and regulation of Krt86, especially in hyperoestrogen treated mice, indicating it might act as a marker for non-receptive uterus. |
topic |
Implantation Uterus Oestrogen Progesterone Keratin 86 |
url |
https://doi.org/10.1186/s12861-020-0208-6 |
work_keys_str_mv |
AT hezhang keratin86isupregulatedintheuterusduringimplantationinducedbyoestradiol AT huashanzhao keratin86isupregulatedintheuterusduringimplantationinducedbyoestradiol AT xiwang keratin86isupregulatedintheuterusduringimplantationinducedbyoestradiol AT xiaolincui keratin86isupregulatedintheuterusduringimplantationinducedbyoestradiol AT linglingjin keratin86isupregulatedintheuterusduringimplantationinducedbyoestradiol |
_version_ |
1724281265801134080 |