Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells

Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells

Schizophrenia is a complex psychiatric disorder that exhibits an interconnection between the immune system and the brain. Experimental and clinical studies have suggested the presence of neuroinflammation in schizophrenia. In the present study, the effect of antipsychotic drugs, including clozapine,...

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Bibliographic Details
Main Authors: Vijayasree V. Giridharan, Giselli Scaini, Gabriela D. Colpo, Tejaswini Doifode, Omar F. Pinjari, Antônio L. Teixeira, Fabricia Petronilho, Danielle Macêdo, João Quevedo, Tatiana Barichello
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
microglia
poly (i:c)
inflammation
nlrp3
cytokines
schizophrenia
Online Access:https://www.mdpi.com/2073-4409/9/3/577

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