Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma

Background: The aim of this study was to characterize the immunohistochemical expression of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma. Materials and Methods: Immunohistochemical staining for galectins 1, 3, and 9 was evaluated in 8 sa...

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Main Authors: Thais Ayako Hossaka, Daniel A Ribeiro, Gustavo Focchi, Sabine André, Mariana Fernandes, Fernando Cintra Lopes Carapeto, Marcelo Souza Silva, Celina T F Oshima
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Dental Research Journal
Subjects:
Online Access:http://www.drjjournal.net/article.asp?issn=1735-3327;year=2014;volume=11;issue=4;spage=508;epage=512;aulast=Hossaka
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spelling doaj-cc1b7749a4fb4f048b224940696bee592020-11-24T22:21:24ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552014-01-0111450851210.4103/1735-3327.139428Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinomaThais Ayako HossakaDaniel A RibeiroGustavo FocchiSabine AndréMariana FernandesFernando Cintra Lopes CarapetoMarcelo Souza SilvaCelina T F OshimaBackground: The aim of this study was to characterize the immunohistochemical expression of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma. Materials and Methods: Immunohistochemical staining for galectins 1, 3, and 9 was evaluated in 8 samples of normal oral squamous epithelium, 15 samples of oral squamous papilloma, and 41 samples of oral squamous cell carcinoma. Immunohistochemical data were assessed by Kruskal-Wallis non-parametric test followed by Dunn′s test. For all analyzes, it was adopted the value of P <0.05 for statistical significance. Results: Significant differences were found in galectin- 3 expression when comparing ordinary mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples. Conclusion: These findings indicate that galectin-3 is closely involved in malignant transformation of oral mucosa cells.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2014;volume=11;issue=4;spage=508;epage=512;aulast=HossakaGalectin-1galectin-3galectin-9oral squamous cell carcinomaoral squamous papilloma
collection DOAJ
language English
format Article
sources DOAJ
author Thais Ayako Hossaka
Daniel A Ribeiro
Gustavo Focchi
Sabine André
Mariana Fernandes
Fernando Cintra Lopes Carapeto
Marcelo Souza Silva
Celina T F Oshima
spellingShingle Thais Ayako Hossaka
Daniel A Ribeiro
Gustavo Focchi
Sabine André
Mariana Fernandes
Fernando Cintra Lopes Carapeto
Marcelo Souza Silva
Celina T F Oshima
Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
Dental Research Journal
Galectin-1
galectin-3
galectin-9
oral squamous cell carcinoma
oral squamous papilloma
author_facet Thais Ayako Hossaka
Daniel A Ribeiro
Gustavo Focchi
Sabine André
Mariana Fernandes
Fernando Cintra Lopes Carapeto
Marcelo Souza Silva
Celina T F Oshima
author_sort Thais Ayako Hossaka
title Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
title_short Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
title_full Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
title_fullStr Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
title_full_unstemmed Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
title_sort expression of galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
publisher Wolters Kluwer Medknow Publications
series Dental Research Journal
issn 1735-3327
2008-0255
publishDate 2014-01-01
description Background: The aim of this study was to characterize the immunohistochemical expression of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma. Materials and Methods: Immunohistochemical staining for galectins 1, 3, and 9 was evaluated in 8 samples of normal oral squamous epithelium, 15 samples of oral squamous papilloma, and 41 samples of oral squamous cell carcinoma. Immunohistochemical data were assessed by Kruskal-Wallis non-parametric test followed by Dunn′s test. For all analyzes, it was adopted the value of P <0.05 for statistical significance. Results: Significant differences were found in galectin- 3 expression when comparing ordinary mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples. Conclusion: These findings indicate that galectin-3 is closely involved in malignant transformation of oral mucosa cells.
topic Galectin-1
galectin-3
galectin-9
oral squamous cell carcinoma
oral squamous papilloma
url http://www.drjjournal.net/article.asp?issn=1735-3327;year=2014;volume=11;issue=4;spage=508;epage=512;aulast=Hossaka
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