Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
Background: The aim of this study was to characterize the immunohistochemical expression of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma. Materials and Methods: Immunohistochemical staining for galectins 1, 3, and 9 was evaluated in 8 sa...
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doaj-cc1b7749a4fb4f048b224940696bee592020-11-24T22:21:24ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552014-01-0111450851210.4103/1735-3327.139428Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinomaThais Ayako HossakaDaniel A RibeiroGustavo FocchiSabine AndréMariana FernandesFernando Cintra Lopes CarapetoMarcelo Souza SilvaCelina T F OshimaBackground: The aim of this study was to characterize the immunohistochemical expression of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma. Materials and Methods: Immunohistochemical staining for galectins 1, 3, and 9 was evaluated in 8 samples of normal oral squamous epithelium, 15 samples of oral squamous papilloma, and 41 samples of oral squamous cell carcinoma. Immunohistochemical data were assessed by Kruskal-Wallis non-parametric test followed by Dunn′s test. For all analyzes, it was adopted the value of P <0.05 for statistical significance. Results: Significant differences were found in galectin- 3 expression when comparing ordinary mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples. Conclusion: These findings indicate that galectin-3 is closely involved in malignant transformation of oral mucosa cells.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2014;volume=11;issue=4;spage=508;epage=512;aulast=HossakaGalectin-1galectin-3galectin-9oral squamous cell carcinomaoral squamous papilloma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thais Ayako Hossaka Daniel A Ribeiro Gustavo Focchi Sabine André Mariana Fernandes Fernando Cintra Lopes Carapeto Marcelo Souza Silva Celina T F Oshima |
spellingShingle |
Thais Ayako Hossaka Daniel A Ribeiro Gustavo Focchi Sabine André Mariana Fernandes Fernando Cintra Lopes Carapeto Marcelo Souza Silva Celina T F Oshima Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma Dental Research Journal Galectin-1 galectin-3 galectin-9 oral squamous cell carcinoma oral squamous papilloma |
author_facet |
Thais Ayako Hossaka Daniel A Ribeiro Gustavo Focchi Sabine André Mariana Fernandes Fernando Cintra Lopes Carapeto Marcelo Souza Silva Celina T F Oshima |
author_sort |
Thais Ayako Hossaka |
title |
Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma |
title_short |
Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma |
title_full |
Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma |
title_fullStr |
Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma |
title_full_unstemmed |
Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma |
title_sort |
expression of galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma |
publisher |
Wolters Kluwer Medknow Publications |
series |
Dental Research Journal |
issn |
1735-3327 2008-0255 |
publishDate |
2014-01-01 |
description |
Background: The aim of this study was to characterize the immunohistochemical expression of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma.
Materials and Methods: Immunohistochemical staining for galectins 1, 3, and 9 was evaluated in 8 samples of normal oral squamous epithelium, 15 samples of oral squamous papilloma, and 41 samples of oral squamous cell carcinoma. Immunohistochemical data were assessed by Kruskal-Wallis non-parametric test followed by Dunn′s test. For all analyzes, it was adopted the value of P <0.05 for statistical significance.
Results: Significant differences were found in galectin- 3 expression when comparing ordinary mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples.
Conclusion: These findings indicate that galectin-3 is closely involved in malignant transformation of oral mucosa cells. |
topic |
Galectin-1 galectin-3 galectin-9 oral squamous cell carcinoma oral squamous papilloma |
url |
http://www.drjjournal.net/article.asp?issn=1735-3327;year=2014;volume=11;issue=4;spage=508;epage=512;aulast=Hossaka |
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