Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period
Abstract Background Small dense low density lipoprotein-cholesterol (sdLDL-C), cholesterol ratios and carotid-femoral pulse wave velocity (cf-PWV) impart risk for all-cause morbidity and mortality independently of conventional cardiovascular disease (CVD) risk factors. This study was designed to ide...
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doaj-cc2a7137d90d45f18c2a65472e1c73d22020-11-24T21:35:55ZengBMCLipids in Health and Disease1476-511X2018-02-0117111010.1186/s12944-018-0671-2Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year periodGang Li0Hui-kun Wu1Xiao-wei Wu2Zhe Cao3Yuan-chao Tu4Yi Ma5Wei-qing Wang6Jian Cheng7Zi-hua Zhou8Emergency Department, Hubei Provincial Hospital of Traditional Chinese MedicineDepartment of Hepatology, Hubei Provincial Hospital of Traditional Chinese MedicineDepartment of Thoracic Surgery, TongJi Hospital, TongJi Medical College, Huazhong University of Science and TechnologyDepartment of Cardiology, The Central Hospital of WuhanHubei Province Academy of Traditional Chinese MedicineEmergency Department, Hubei Provincial Hospital of Traditional Chinese MedicineEmergency Department, Hubei Provincial Hospital of Traditional Chinese MedicineEmergency Department, Wuhan General Hospital of Guangzhou Military CommandInstitute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science & TechnologyAbstract Background Small dense low density lipoprotein-cholesterol (sdLDL-C), cholesterol ratios and carotid-femoral pulse wave velocity (cf-PWV) impart risk for all-cause morbidity and mortality independently of conventional cardiovascular disease (CVD) risk factors. This study was designed to identify feasible indicators for predicting arterial stiffness progression. Methods We followed up 816 normotensive participants without diabetes or CVD for nearly 5.0 years. Cholesterol parameters, ratios and other clinical and laboratory data were collected at baseline. cf-PWV were measured at baseline and the end of follow-up. Results PWV progression subjects had higher levels of PWV parameters, sdLDL-C and TG/HDL-C ratio. sdLDL-C and TG/HDL-C were significantly correlated with all PWV parameters. Multiple regression models showed that sdLDL-C was closely associated with follow-up PWV (β = 0.222, p < 0.001) and △PWV (β = 0.275, p < 0.001). TG/HDL-C was only one cholesterol ratios that associated with all PWV parameters. sdLDL-C (OR = 2.070, 95%CI: 1.162 to 3.688, p = 0.014) and TG/HDL-C (OR = 1.355, 95%CI: 1.136 to 1.617, p = 0.001) could significantly determine the progression of PWV after correction for covariates. High sd-LDL-C quantiles subjects were more likely to develop arterial stiffness progression than low quantiles (Tertiles 3 vs Tertiles1, RR = 2.867, 95%CI: 1.106 to 7.434, p = 0.03). Conclusion We founded that sdLDL-C and TG/HDL-C ratio can independently predict arterial stiffness progression in normotensive subjects, and high level sdLDL-C and TG/HDL-C ratio were associated with a higher risk of arterial stiffness.http://link.springer.com/article/10.1186/s12944-018-0671-2sdLDL-CCholesterol ratiosArterial stiffnessNormotensive |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gang Li Hui-kun Wu Xiao-wei Wu Zhe Cao Yuan-chao Tu Yi Ma Wei-qing Wang Jian Cheng Zi-hua Zhou |
spellingShingle |
Gang Li Hui-kun Wu Xiao-wei Wu Zhe Cao Yuan-chao Tu Yi Ma Wei-qing Wang Jian Cheng Zi-hua Zhou Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period Lipids in Health and Disease sdLDL-C Cholesterol ratios Arterial stiffness Normotensive |
author_facet |
Gang Li Hui-kun Wu Xiao-wei Wu Zhe Cao Yuan-chao Tu Yi Ma Wei-qing Wang Jian Cheng Zi-hua Zhou |
author_sort |
Gang Li |
title |
Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period |
title_short |
Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period |
title_full |
Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period |
title_fullStr |
Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period |
title_full_unstemmed |
Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period |
title_sort |
small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2018-02-01 |
description |
Abstract Background Small dense low density lipoprotein-cholesterol (sdLDL-C), cholesterol ratios and carotid-femoral pulse wave velocity (cf-PWV) impart risk for all-cause morbidity and mortality independently of conventional cardiovascular disease (CVD) risk factors. This study was designed to identify feasible indicators for predicting arterial stiffness progression. Methods We followed up 816 normotensive participants without diabetes or CVD for nearly 5.0 years. Cholesterol parameters, ratios and other clinical and laboratory data were collected at baseline. cf-PWV were measured at baseline and the end of follow-up. Results PWV progression subjects had higher levels of PWV parameters, sdLDL-C and TG/HDL-C ratio. sdLDL-C and TG/HDL-C were significantly correlated with all PWV parameters. Multiple regression models showed that sdLDL-C was closely associated with follow-up PWV (β = 0.222, p < 0.001) and △PWV (β = 0.275, p < 0.001). TG/HDL-C was only one cholesterol ratios that associated with all PWV parameters. sdLDL-C (OR = 2.070, 95%CI: 1.162 to 3.688, p = 0.014) and TG/HDL-C (OR = 1.355, 95%CI: 1.136 to 1.617, p = 0.001) could significantly determine the progression of PWV after correction for covariates. High sd-LDL-C quantiles subjects were more likely to develop arterial stiffness progression than low quantiles (Tertiles 3 vs Tertiles1, RR = 2.867, 95%CI: 1.106 to 7.434, p = 0.03). Conclusion We founded that sdLDL-C and TG/HDL-C ratio can independently predict arterial stiffness progression in normotensive subjects, and high level sdLDL-C and TG/HDL-C ratio were associated with a higher risk of arterial stiffness. |
topic |
sdLDL-C Cholesterol ratios Arterial stiffness Normotensive |
url |
http://link.springer.com/article/10.1186/s12944-018-0671-2 |
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