Clinical efficacy of an anticolinergic agent in HAM/TPS patients with neurogenic bladder

• Main Authors: Néviton Matos de Castro, Daniel Meira Freitas, Waldyr Rodrigues Jr, Paulo Oliveira, André Muniz, Edgar Marcelino de Carvalho
• Format: Article
• Language: English
• Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2005-12-01
• Series: Einstein (São Paulo)
• Subjects: Human T-lymphotropic virus 1; Paraparesis; tropical spastic; Cholinergic antagonists; Bladder; neurogenic
• Online Access: http://www.einstein.br/revista/biblioteca/artigos/vol3/num_4/Vol3_N4_P251.pdf
• ISSN: 1679-4508

Objective: To describe the efficacy of the propantheline bromide inneurogenic bladder in HTLV-I infected patients. Methods: From January/2001 to February/2004, twenty-one HTLV-I-carriers (7 men and 14 women)were selected for treatment with propantheline bromide 15 mg, PO, 2 to 3times a day for 3 months, not discontinuing in the follow-up. At the end ofthe treatment period, patients were revaluated through specificquestionnaires for urinary symptoms (UDI) and quality of life (Ditrovie).Results: From the 21 patients enrolled, 15 (71.4%) presented importantclinical improvement, referring decrease of urinary frequency, urgencyand loss, nocturia, and even total control of the dysfunction. Conclusion:We observed an efficient response to the anticholinergic agentpropantheline bromide in urinary dysfunction caused by the HTLV-I.