Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection
We conducted an international multicenter retrospective cohort study, PregOuTCOV, to examine the effect of gestational age at time of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on obstetric and neonatal outcomes. We included all singleton pregnancies with a live fet...
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Centers for Disease Control and Prevention
2021-10-01
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doaj-cc3f17b7c203417c8a97ed38ebdd8dfa2021-09-20T16:37:59ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-10-0127102535254310.3201/eid2710.211394Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of InfectionDominique A. BadrOlivier PiconeElisa BevilacquaAndrew CarlinFederica MeliJeanne SibiudeJérémie MatternJean-François FilsLaurent MandelbrotAntonio LanzoneDanièle De LucaJacques C. JaniAlexandre J. Vivanti We conducted an international multicenter retrospective cohort study, PregOuTCOV, to examine the effect of gestational age at time of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on obstetric and neonatal outcomes. We included all singleton pregnancies with a live fetus at 10 weeks’ gestation in which pregnancy outcomes were known. The exposed group consisted of patients infected with SARS-CoV-2, whereas the unexposed group consisted of all remaining patients during the same period. Primary outcomes were defined as composite adverse obstetric outcomes and composite adverse neonatal outcomes. Of 10,925 pregnant women, 393 (3.60%) were infected with SARS-CoV-2 (exposed group). After matching for possible confounders, we identified statistically significant increases in the exposed group of composite adverse obstetric outcomes at >20 weeks’ gestation and of composite adverse neonatal outcomes at >26 weeks’ gestation (p<0.001). Vaccination programs should target women early in pregnancy or before conception, if possible. https://wwwnc.cdc.gov/eid/article/27/10/21-1394_articleCOVID-19coronavirus diseaseSARS-CoV-2severe acute respiratory syndrome coronavirus 2virusesrespiratory infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dominique A. Badr Olivier Picone Elisa Bevilacqua Andrew Carlin Federica Meli Jeanne Sibiude Jérémie Mattern Jean-François Fils Laurent Mandelbrot Antonio Lanzone Danièle De Luca Jacques C. Jani Alexandre J. Vivanti |
spellingShingle |
Dominique A. Badr Olivier Picone Elisa Bevilacqua Andrew Carlin Federica Meli Jeanne Sibiude Jérémie Mattern Jean-François Fils Laurent Mandelbrot Antonio Lanzone Danièle De Luca Jacques C. Jani Alexandre J. Vivanti Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection Emerging Infectious Diseases COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections |
author_facet |
Dominique A. Badr Olivier Picone Elisa Bevilacqua Andrew Carlin Federica Meli Jeanne Sibiude Jérémie Mattern Jean-François Fils Laurent Mandelbrot Antonio Lanzone Danièle De Luca Jacques C. Jani Alexandre J. Vivanti |
author_sort |
Dominique A. Badr |
title |
Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection |
title_short |
Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection |
title_full |
Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection |
title_fullStr |
Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection |
title_full_unstemmed |
Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection |
title_sort |
severe acute respiratory syndrome coronavirus 2 and pregnancy outcomes according to gestational age at time of infection |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2021-10-01 |
description |
We conducted an international multicenter retrospective cohort study, PregOuTCOV, to examine the effect of gestational age at time of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on obstetric and neonatal outcomes. We included all singleton pregnancies with a live fetus at 10 weeks’ gestation in which pregnancy outcomes were known. The exposed group consisted of patients infected with SARS-CoV-2, whereas the unexposed group consisted of all remaining patients during the same period. Primary outcomes were defined as composite adverse obstetric outcomes and composite adverse neonatal outcomes. Of 10,925 pregnant women, 393 (3.60%) were infected with SARS-CoV-2 (exposed group). After matching for possible confounders, we identified statistically significant increases in the exposed group of composite adverse obstetric outcomes at >20 weeks’ gestation and of composite adverse neonatal outcomes at >26 weeks’ gestation (p<0.001). Vaccination programs should target women early in pregnancy or before conception, if possible.
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topic |
COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections |
url |
https://wwwnc.cdc.gov/eid/article/27/10/21-1394_article |
work_keys_str_mv |
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