Regulation of Heparanase in Diabetes-Associated Pancreatic Carcinoma

Regulation of Heparanase in Diabetes-Associated Pancreatic Carcinoma

While at least six types of cancer have been associated with diabetes, pancreatic ductal adenocarcinoma (PDAC) and diabetes exhibit a unique bidirectional relationship. Recent reports indicate that majority of PDAC patients display hyperglycemia, and ~50% have concurrent diabetes. In turn, hyperglyc...

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Bibliographic Details
Main Authors: Rachel Goldberg, Amichay Meirovitz, Alexia Abecassis, Esther Hermano, Ariel M. Rubinstein, Daniela Nahmias, Albert Grinshpun, Tamar Peretz, Michael Elkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Oncology
Subjects:
heparanase
pancreatic carcinoma
diabetes
hyperglycemia
extracellular matrix
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01405/full

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