The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells

The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells

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Epigenetic mechanisms such as DNA methylation and histone modification are important in stem cell differentiation. Methylation is principally associated with transcriptional repression, and histone acetylation is correlated with an active chromatin state. We determined the effects of these epigeneti...

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Bibliographic Details
Main Authors: J. Zych, M.A. Stimamiglio, A.C. Senegaglia, P.R.S. Brofman, B. Dallagiovanna, S. Goldenberg, A. Correa
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2013-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Mesenchymal stem cells
Trichostatin A
5-Aza-2′-deoxycytidine
Adipocyte differentiation
Epigenetics
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000500405

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